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1. (US20150361085) Solid forms of an antiviral compound

Office : United States of America
Application Number: 14733101 Application Date: 08.06.2015
Publication Number: 20150361085 Publication Date: 17.12.2015
Grant Number: 09630972 Grant Date: 25.04.2017
Publication Kind : B2
IPC:
C07D 491/052
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
044
with only one oxygen atom as ring hetero atom in the oxygen-containing ring
052
the oxygen-containing ring being six-membered
Applicants: Gilead Pharmasset LLC
Inventors: Olga Viktorovna Lapina
Bing Shi
Fang Wang
Scott Alan Wolckenhauer
Priority Data:
Title: (EN) Solid forms of an antiviral compound
Abstract: front page image
(EN)

Crystalline solid forms of methyl {(2S)-1-[(2S,5S)-2-(9-{2-[(2S,4S)-1-{(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl}-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl}-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl)-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl}carbamate (Compound I) were prepared and characterized in the solid state:

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Also provided are processes of manufacture and methods of using these crystalline forms.