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Machine translation
2. (US20150344834) System, method and devices for tissue-based diagnosis
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Application Number: 14591792 Application Date: 07.01.2015
Publication Number: 20150344834 Publication Date: 03.12.2015
Grant Number: 09328324 Grant Date: 03.05.2016
Publication Kind : B2
IPC:
A61B 10/00
C12M 1/42
C12M 1/00
A61B 10/02
A61M 37/00
G01N 1/28
G01N 1/40
A61B 10/04
A61B 18/20
A61B 17/00
A61B 17/32
A61B 18/00
A61N 7/02
G01N 1/44
CPC:
A61B 10/02
A61B 10/0045
A61B 10/0096
A61B 10/0283
A61B 10/04
A61B 18/04
A61B 18/20
A61B2010/0208
A61B2017/00761
A61B2017/320004
A61B2018/00452
A61K 31/522
A61K 38/28
A61M 37/0015
A61M2037/0023
A61M2037/0046
A61N 7/00
A61N 7/02
A61N2007/0034
C12M 23/28
C12M 31/00
C12M 35/08
G01N 1/286
G01N 1/4044
G01N 1/44
Y10T 436/2575
Applicants: The Regents of the University of California
Inventors: Samir Mitragotri
Sumit Paliwal
Makoto Ogura
Agents: Pabst Patent Group LLP
Priority Data:
Title: (EN) System, method and devices for tissue-based diagnosis
Abstract:
(EN)

Described are devices, methods and systems for applying energy and/or a liquefaction promoting medium to a tissue of interest to generate a liquefied tissue sample. The liquefied tissue sample may be removed from the tissue of interest. Also described are compositions of the liquefaction promoting medium that may facilitate liquefaction, preserve liquefied tissue constituents, and/or enable delivery of molecules into tissues. The sample may include tissue constituents to provide for rapid tissue sampling, tissue decontamination as well as detection of analytes. One or more drugs may be delivered through or into the tissue of interest. Determination of tissue composition in the liquefied tissue sample can be used, e.g., for diagnosis or prognosis of diseases, evaluating bioavailability of therapeutic agents in different tissues following administration, forensic detection of drugs-of-abuse, evaluating changes in the tissue microenvironment following exposure to a harmful agent, and the like.