US20150166489 Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof

Settings

Stemming

Single Family Member

Include NPL

Feedback

Goto Application

Office

United States of America

Application Number 14627573

Application Date 20.02.2015

Publication Number 20150166489

Publication Date 18.06.2015

Grant Number 09273014

Grant Date 01.03.2016

Publication Kind B2

IPC

View more classifications

View less classifications

CPC

View more classifications

View less classifications

Applicants Bristol-Myers Squibb Company

Inventors Ashvinikumar V. Gavai
George V. DeLucca
Daniel O'Malley
Patrice Gill
Claude A. Quesnelle
Brian E. Fink
Yufen Zhao
Francis Y. Lee

Agents Gary D. Greenblatt

Title

(EN) Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof

Abstract

(EN)

Disclosed are compounds of Formula (I) and/or salts thereof:

wherein R₁is —CH₂CH₂CF₃; R₂is —CH₂CH₂CF₃or —CH₂CH₂CH₂CF₃; R₃is H, —CH₃, or R_x; R₄is H or R_y; Ring A is phenyl or pyridinyl; and R_x, R_y, R_a, R_b, y, and z are defined herein. Also disclosed are methods of using such compounds to inhibit the Notch receptor, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as cancer; or as prodrugs of such compounds.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38	Medicinal preparations containing peptides

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
243	Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
06	having the nitrogen atoms in positions 1 and 4
10	condensed with carbocyclic rings or ring systems
14	1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
16	substituted in position 5 by aryl radicals
18	substituted in position 2 by nitrogen, oxygen or sulfur atoms
24	Oxygen atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55	having seven-membered rings, e.g. azelastine, pentylenetetrazole
551	having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep
5513	1,4-Benzodiazepines, e.g. diazepam

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
56	Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
57	substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, progesterone
573	substituted in position 21, e.g. cortisone, dexamethasone, prednisone

Processing

National Phase Entries

Authority File

Settings

Feedback

Goto Application

1. US20150166489 - Bis(fluoroalkyl)-1,4-benzodiazepinone compounds and prodrugs thereof

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9	Compounds containing elements of Groups 5 or 15 of the Periodic System
02	Phosphorus compounds
547	Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645	having two nitrogen atoms as the only ring hetero atoms

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
K	PEPTIDES
5	Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04	containing only normal peptide links
06	Dipeptides
062	the side chain of the first amino acid being acyclic, e.g. Gly, Ala

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7	Compounds containing elements of Groups 4 or 14 of the Periodic System
02	Silicon compounds
08	Compounds having one or more C—Si linkages
18	Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
1804	Compounds having Si-O-C linkages

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0012	Galenical forms characterised by the site of application
0019	Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9	Medicinal preparations characterised by special physical form
0087	Galenical forms not covered by A61K9/02 - A61K9/7023
0095	Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches