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1. US20150083906 - BIOMARKERS FOR MONITORING INTERVENTION THERAPIES FOR DIABETES

Office
United States of America
Application Number 14394872
Application Date 16.04.2013
Publication Number 20150083906
Publication Date 26.03.2015
Publication Kind A1
IPC
G01N 33/96
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
96involving blood or serum control standard
H01J 49/16
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
10Ion sources; Ion guns
16using surface ionisation, e.g. field-, thermionic- or photo-emission
H01J 49/34
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
26Mass spectrometers or separator tubes
34Dynamic spectrometers
CPC
G01N 33/96
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
96involving blood or serum control standard
H01J 49/34
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
26Mass spectrometers or separator tubes
34Dynamic spectrometers
H01J 49/164
HELECTRICITY
01BASIC ELECTRIC ELEMENTS
JELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
49Particle spectrometers or separator tubes
02Details
10Ion sources; Ion guns
16using surface ionisation, e.g. field-, thermionic- or photo-emission
161using photoionisation, e.g. by laser
164Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
Applicants MERCK SHARP & DOHME CORP.
Inventors Huseyin Mehmet
Sandra C. Souza
Hidehisa Asada
Yoshiaki Miura
Taku Nakahara
Diane McCarthy
Title
(EN) BIOMARKERS FOR MONITORING INTERVENTION THERAPIES FOR DIABETES
Abstract
(EN)

The use of N-linked glycosylation pattern of serum proteins as a biomarker for evaluating the efficacy of intervention therapies for diabetes is disclosed. As disclosed herein, changes in the N-linked glycosylation of total plasma proteins precedes and predicts the decrease in glycated hemoglobin (HbA1c) associated with successful treatment of diabetes. Therefore, measuring changes in N-linked glycosylation of total serum plasma proteins over time may be used as a biomarker to evaluate or access the efficacy of an intervention therapy for diabetes.

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