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1. (US20150080577) Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv

Office : United States of America
Application Number: 14552550 Application Date: 25.11.2014
Publication Number: 20150080577 Publication Date: 19.03.2015
Grant Number: 09115077 Grant Date: 25.08.2015
Publication Kind : B2
IPC:
C07D 215/00
C07D 231/12
C07C 67/475
C07C 231/12
C07C 235/40
C07D 307/33
C07D 417/04
C07D 453/04
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
215
Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
231
Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02
not condensed with other rings
10
having two or three double bonds between ring members or between ring members and non-ring members
12
with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
67
Preparation of carboxylic acid esters
475
by splitting of carbon-to-carbon bonds and redistribution, e.g. disproportionation or migration of groups between different molecules
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
231
Preparation of carboxylic acid amides
12
by reactions not involving the formation of carboxamide groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
235
Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
40
having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
26
having one double bond between ring members or between a ring member and a non-ring member
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
32
Oxygen atoms
33
in position 2, the oxygen atom being in its keto or unsubstituted enol form
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
453
Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02
containing not further condensed quinuclidine ring systems
04
having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
Applicants: Janssen Pharmaceutica NV
Inventors: Andras Horvath
Dominic John Ormerod
Dominique Paul Michel Depre
Veronique Cerpentier
Agents: Andrea Jo Kamage
Priority Data: 08172691 23.12.2008 EP
Title: (EN) Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
Abstract: front page image
(EN)

The present invention relates to the cinchonidine salt

embedded image
useful in the preparation of intermediates for preparing a macrocyclic HCV inhibitor, as well as processes involving this salt.


Also published as:
AR074863IL213246MXMX/a/2011/006764EP2382198JP2012513381US20110257403
CN102264715RU2011130895CA2745565ES2429013PT2382198MX2011006764
KR1020110099048BRPI0923393RU0002588132DK2382198AU2009331530IN1505/MUMNP/2011
RU2016120007WO/2010/072742