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1. (US20150065821) Nanoparticle Phoresis
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Claims

1. A wearable device, comprising:
a mount configured to mount the wearable device to an external body surface proximate to a portion of subsurface vasculature;
a magnet configured to direct a magnetic field into the portion of subsurface vasculature, wherein the magnetic field is sufficient to cause functionalized magnetic particles to collect in a lumen of the portion of the subsurface vasculature, wherein the functionalized magnetic particles are configured to complex with a target, and wherein the target has an ability to cause an adverse health effect;
a signal source configured to transmit a signal into the portion of subsurface vasculature sufficient to cause a physical or chemical change in the target complexed with the functionalized magnetic particles, wherein the physical or chemical change reduces or eliminates the target's ability to cause the adverse health effect.
2. The wearable device of claim 1, wherein the functionalized magnetic particles are configured to complex with the target by binding to the target.
3. The wearable device of claim 1, wherein the functionalized magnetic particles are configured to complex with the target by binding to other functionalized particles that are bound to the target.
4. The wearable device of claim 1, wherein the signal comprises an electromagnetic pulse, an acoustic pulse, or a time-varying magnetic field.
5. The wearable device of claim 1, wherein the signal comprises an infrared pulse.
6. The wearable device of claim 1, wherein the signal comprises a radio frequency pulse.
7. The wearable device of claim 1, further comprising:
a detector configured to detect a response signal transmitted from the portion of subsurface vasculature, wherein the response signal is related to complexing of the target to the functionalized magnetic particles.
8. The wearable device of claim 7, further comprising:
a signal source configured to transmit an interrogating signal into the portion of subsurface vasculature, wherein the response signal is generated in response to the interrogating signal.
9. A method, comprising:
introducing functionalized magnetic particles into a lumen of subsurface vasculature, wherein the functionalized magnetic particles are configured to complex with a target in blood circulating in the subsurface vasculature, wherein the target has an ability to cause an adverse health effect;
directing, from a magnet in the wearable device, a magnetic field into the subsurface vasculature proximate to the wearable device, wherein the magnetic field is sufficient to cause the functionalized magnetic particles complexed with the target to collect in a lumen of the subsurface vasculature proximate to the wearable device;
directing, from a signal source in the wearable device, a signal into the portion of subsurface vasculature sufficient to cause a physical or chemical change in the target complexed with the functionalized magnetic particles, wherein the physical or chemical change reduces or eliminates the target's ability to cause the adverse health effect.
10. The method of claim 9, wherein the signal comprises an electromagnetic pulse, an acoustic pulse, or a time-varying magnetic field.
11. The method of claim 10, wherein the signal comprises a radio frequency pulse.
12. The method of claim 10, wherein the signal comprises an infrared light pulse.
13. The method of claim 9, wherein the target comprises a protein, a hormone, or a cell.
14. The method of claim 9, wherein the functionalized magnetic particles are configured to complex with the target by binding to the target.
15. The method of claim 9, wherein the functionalized magnetic particles are configured to complex with the target by binding to other functionalized particles that are bound to the target.
16. The method of claim 9, further comprising automatically measuring, by the wearable device, one or more physiological parameters during each of a plurality of measurement periods, wherein at least one of the physiological parameters is measured by non-invasively detecting one or more analytes in blood circulating in subsurface vasculature proximate to the wearable device.
17. A method, comprising:
introducing a first type of functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles of the first type are magnetic;
introducing a second type of functionalized particles into a lumen of subsurface vasculature, wherein the functionalized particles of the second type are configured to bind to a target in blood circulating in the subsurface vasculature, wherein the target has an ability to cause an adverse health effect;
wherein the functionalized particles of the first type are configured to bind to functionalized particles of the second type that are bound to the target;
directing, from a magnet in the wearable device, a magnetic field into the subsurface vasculature proximate to the wearable device, wherein the magnetic field is sufficient to cause functionalized particles of the first type bound to functionalized particles of the second type to collect in a lumen of the subsurface vasculature proximate to the wearable device;
directing, from a signal source in the wearable device, a signal into the portion of subsurface vasculature sufficient to cause a physical or chemical change in the target bound to functionalized particles of the second type, wherein the physical or chemical change reduces or eliminates the target's ability to cause the adverse health effect.
18. The method of claim 17, wherein the functionalized particles of the second set undergo a conformational change exposing a binding site when bound to the target and wherein the functionalized particles of the first set are configured to bind to the binding site.
19. The method of claim 17, wherein the signal comprises an electromagnetic pulse.
20. The method of claim 19, wherein the electromagnetic pulse is a radio frequency pulse.