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1. SG183872 - THERAPEUTIC DLL4 BINDING PROTEINS

Office Singapore
Application Number 2012065066
Application Date 28.02.2011
Publication Number 183872
Publication Date 29.11.2012
Publication Kind A
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
C07K 16/18
CPC
C07K 16/28
C07K 2317/24
A61K 38/17
A61K 38/18
A61K 39/395
A61K 48/00
Applicants ABBVIE INC.
Inventors LI, YINGCHUN
GU, JIJIE, JAMES
MORGAN-LAPPE, SUSAN
CHEN, MINGJIU
HSIEH, CHUNG-MING
Priority Data 61/309,494 02.03.2010 US
Title
(EN) THERAPEUTIC DLL4 BINDING PROTEINS
Abstract
(EN)
DLL4 binding proteins are described herein, including antibodies, CDR-grafted antibodies, humanized antibodies, and DLL4 binding fragments thereof, proteins that bind DLL4 with high affinity, and DLL4 binding proteins that neutralize DLL4 and/or VEGF activity. The DLL4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis.