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1. (SG178351) COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS

Office : Singapore
Application Number: 2012009304 Application Date: 27.08.2010
Publication Number: 178351 Publication Date: 29.03.2012
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2010046930 ; Publication Number:2011025927 Click to see the data
IPC:
C07D 401/14
C07D 403/04
A61K 31/506
A61P 35/00
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants: IRM LLC
NOVARTIS AG
Inventors: HUANG, SHENLIN
JIN, XIANMING
LIU, ZUOSHENG
POON, DANIEL
TELLEW, JOHN E.
WAN, YONGQIN
WANG, XING
XIE, YONGPING
Priority Data: 61/238,073 28.08.2009 US
61/313,039 11.03.2010 US
Title: (EN) COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS
Abstract:
(EN) The invention provides a novel class of compounds of formula 1, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of B-Raf.
Also published as:
RSP-2014/0430UAa201203042IL218084EP2470526DOP2012000051JP2013503186
CN102725283CA2771775EA201200373EP2727918ES2492499KR1020120062839
TN2012000081NZ598924DK2470526AU2010286569VN30470ID2012/03594
TH140028IN2469/DELNP/2012WO/2011/025927