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1. SG172257 - METHOD OF MAKING SMALL LIPOSOMES

Office Singapore
Application Number 2011044831
Application Date 17.12.2009
Publication Number 172257
Publication Date 28.07.2011
Publication Kind A
CPC
C07F 9/10
A61K 9/1277
A61K 39/00
Applicants ONCOTHYREON, INC.
Inventors DUPUIT, ROBERT, A.
REILLEY, WILLIAM, J.
Priority Data 61/138,353 17.12.2008 US
Title
(EN) METHOD OF MAKING SMALL LIPOSOMES
Abstract
(EN)
Liposomes of constrained particle size are prepared by substantially continuously mixing substantially continuously flowing streams of water, and of an organic solvent contain lipid(s) capable of forming liposomes, and cooling the mixture so liposomes form, the ratio of the flow rate of the stream of water to the flow rate of the stream of organic solvent, and the rate of cooling of said mixture, being controlled so as to obtain a preparation of liposomes such that at least about 90% of the liposomes are of a particle size less than about 200 nm.

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