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1. (SG172195) COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS

Office : Singapore
Application Number: 2011044088 Application Date: 17.12.2009
Publication Number: 172195 Publication Date: 28.07.2011
Publication Kind : A
Prior PCT appl.: Application Number:PCTUS2009068492 ; Publication Number:2010078042 Click to see the data
CPC:
A61K 45/06
A61K 38/164
C07K 14/21
Y02A 50/423
Applicants: CDG THERAPEUTICS, INC.
Inventors: DAS GUPTA, TAPAS
MEHTA, RAJENDRA, G.
MEHTA, RAJESHWARI
BEATTIE, CRAIG
Priority Data: 12337167 17.12.2008 US
Title: (EN) COMPOSITIONS AND METHODS TO PREVENT CANCER WITH CUPREDOXINS
Abstract:
(EN) The present invention relates to compositions and methods comprising chemopreventive agents that may be cupredoxin(s) or variants, derivatives and structural equivalents of cupredoxins, and at least one other chemopreventive agent. Specifically, these compositions may comprise azurin from Pseudomonas aeruginosa, and/or the 50-77 residue region of azurin (p28). The at least one other chemopreventive agent may comprise an antiestrogen such as Tamoxifen. The compositions of the invention may be used to prevent the development of premalignant lesions in mammalian cells, tissues and animals, and thus prevent cancer.
Also published as:
IL213657EP2379097JP2012512259CN102316887CA2747404KR1020110126595
AU2009333174IN5232/DELNP/2011WO/2010/078042