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1. (SG172152) 1, 2, 4 -OXADIAZOLE DERIVATIVES AND THEIR THERAPEUTIC USE

Office : Singapore
Application Number: 2011043510 Application Date: 15.12.2009
Publication Number: 172152 Publication Date: 28.07.2011
Publication Kind : A
Prior PCT appl.: Application Number:PCTEP2009008968 ; Publication Number:2010072352 Click to see the data
CPC:
C07D 413/04
C07D 413/14
C07D 471/04
Applicants: ALMIRALL, S.A.
Inventors: GIULIO MATASSA, VICTOR
AGUILAR IZQUIERDO, NURIA
MIR CEPEDA, MARTA
CARRASCAL RIERA, MARTA
FONQUERNA POU, SILVIA
CARDUS FIGUERAS, ARANZAZU
CASTRO PALOMINO LARIA, JULIO, CESAR
ERRA SOLA, MONTSERRAT
Priority Data: 08382090 26.12.2008 EP
Title: (EN) 1, 2, 4 -OXADIAZOLE DERIVATIVES AND THEIR THERAPEUTIC USE
Abstract:
(EN) New derivatives of general formula (I), or pharmaceutically acceptable salts or N- oxides thereof wherein,either (i) A is selected from the group consisting of -N-, -O- and -S-; B and C are independently selected from the group consisting of -N- and -O-, with the proviso that two of A, B and C are nitrogen atoms, or (ii) two of A, B and C are -N- and one of A, B and C is -NH-; G1 is selected from the group consisting of -CH2-, -NH- and -O-; G2 is selected from the group consisting of -NR4- and -O-; R1 represents: > a 8 to 10 membered bicyclic N-containing heteroaryl group optionally substituted with a C1-4 carboxyalkyl group or a C1-4 aminoalkyl group, > a pyridyl group optionally substituted with one or more substituents selected from hydroxy groups, C1-4 alkyl groups, C1-4 carboxyalkyl groups, C1-4 haloalkyl groups, C1-4 alkoxy groups, amino groups, C1-4 aminoalkyl groups and C1-4 aminoalkoxy groups, > a pyridone group substituted with one or more C1-4 alkyl groups; C1-4 haloalkyl groups or C1-4 aminoalkyl groups, or > a group of formula:
Also published as:
NZ592798UAa201109217IL213168EP2370431MXMX/a/2011/006505JP2012513958
US20110311485CN102264731CA2748397EA201100975KR1020110104075BRPI0918194
AU2009331959VN28274ID2012/01220MYPI 2011002991IN4908/DELNP/2011WO/2010/072352