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1. SG10201912558Y - 3' UTR SEQUENCES FOR STABILIZATION OF RNA

Office
Singapore
Application Number 10201912558Y
Application Date 05.10.2016
Publication Number 10201912558Y
Publication Date 27.02.2020
Publication Kind A1
CPC
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 33/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33Antiparasitic agents
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants BIONTECH RNA PHARMACEUTICALS GMBH
TRON - TRANSLATIONALE ONKOLOGIE AN DER UNIVERSIT√ĄTSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSIT√ĄT MAINZ GGMBH
Inventors ORLANDINI VON NIESSEN, Alexandra
FESSER, Stephanie
VALLAZZA, Britta
BEISSERT, Tim
KUHN, Andreas
SAHIN, Ugur
POLEGANOV, Marco Alexander
Priority Data PCT/EP2015/073180 07.10.2015 EP
Title
(EN) 3' UTR SEQUENCES FOR STABILIZATION OF RNA
Abstract
(EN)
206 3' UTR SEQUENCES FOR STABILIZATION OF RNA Abstract The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'- untranslated region (UTR) of an RNA molecule improve stability and translation efficiency. [Figure 2A]