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1. (SG11201806688Q) TLR7 AGONIST TRIFLUOROACETATE SALT AND CRYSTALLINE FORM B THEREOF, PREPARATION METHODS AND USES

Office : Singapore
Application Number: 11201806688Q Application Date: 04.02.2017
Publication Number: 11201806688Q Publication Date: 27.09.2018
Publication Kind : A1
Prior PCT appl.: Application Number:PCTCN2017072894 ; Publication Number:2017133687 Click to see the data
IPC:
C07D 487/04
A61K 31/519
A61P 31/12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants: CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.
Inventors: DING, Zhaozhong
SUN, Fei
HU, Yinghu
ZHOU, Yilong
WANG, Zheng
ZHAO, Rui
YANG, Ling
Priority Data: 201610081899.3 05.02.2016 CN
Title: (EN) TLR7 AGONIST TRIFLUOROACETATE SALT AND CRYSTALLINE FORM B THEREOF, PREPARATION METHODS AND USES
Abstract:
(EN) 23 TLR7 AGONIST TRIFLUOROACETATE SALT AND CRYSTALLINE FORM B THEREOF, PREPARATION METHODS AND USES Abstract The present invention relates to a trifluoroacetate salt of a TLR7 agonist 2-butoxy-7-(4-(pyrrolidin-1-ylmethyl)benzyl)-5H-pyrrolo[3,2-d]pyrimidin-4-amine (formula I), crystalline form B of the trifluoroacetate salt, methods for preparing the trifluoroacetate salt and crystalline form B, and uses of the trifluoroacetate salt and crystalline form B.
Also published as:
UAa201809128AU2017214135CA3013521MYPI 2018702700KR1020180104118CN108602833
EP3412674IL260981BR112018015878US20190031666IN201817032726EA201891772
ID2018/12857PH1/2018/501641WO/2017/133687