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1. (SG11201806567W) COMPOSITIONS OF INFLUENZA HEMAGGLUTININ WITH HETEROLOGOUS EPITOPES AND/OR ALTERED MATURATION CLEAVAGE SITES

Office : Singapore
Application Number: 11201806567W Application Date: 02.02.2017
Publication Number: 11201806567W Publication Date: 30.08.2018
Publication Kind : A1
Prior PCT appl.: Application Number:PCTUS2017016251 ; Publication Number:2017136575 Click to see the data
IPC:
G01N 33/53
A61K 39/145
A61K 39/155
A61P 31/16
C07K 14/115
C07K 14/285
C12N 15/44
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
145
Orthomyxoviridae, e.g. influenza virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
155
Paramyxoviridae, e.g. parainfluenza virus
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
16
for influenza or rhinoviruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005
from viruses
08
RNA viruses
115
Paramyxoviridae, e.g. parainfluenza virus
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
285
from Pasteurellaceae (F), e.g. Haemophilus influenza
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
31
Genes encoding microbial proteins, e.g. enterotoxins
33
Genes encoding viral proteins
40
Proteins from RNA viruses, e.g. flaviviruses
44
Orthomyxoviridae, e.g. influenza virus
CPC:
A61K 39/12
A61K 2039/5256
C07K 14/005
C07K 2319/40
C07K 2319/50
C12N 2760/16121
C12N 2760/16122
C12N 2760/16134
H01L 23/50
H01L 23/5223
H01L 23/5227
H03H 7/0115
A61K 39/145
A61P 31/16
C12N 15/70
C12N 2760/16234
C12N 2760/16222
H01L 23/66
H03F 1/0222
H03F 1/565
H03F 3/193
H03F 3/195
H03F 2200/294
H03F 2200/408
H03F 2200/451
H04B 1/40
Applicants: CG DISCOVERY, INC.
Inventors: LUO, Chun;
Priority Data: 62/290,894 03.02.2016 US
Title: (EN) COMPOSITIONS OF INFLUENZA HEMAGGLUTININ WITH HETEROLOGOUS EPITOPES AND/OR ALTERED MATURATION CLEAVAGE SITES
Abstract:
(EN) - Figure:6. CR8020Ca grobular head k. domain: stem_ domain membrane W O 20 17 / 136575 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/136575 Al 10 August 2017 (10.08.2017) WIPO I PCT 111111 11111111 0 111011111111111 010 11111 01110111 01111111100 II 1111111111111 0111111 (51) International Patent Classification: G01N 33/53 (2006.01) C07K 14/115 (2006.01) A61K 39/145 (2006.01) C07K 14/285 (2006.01) A61K 39/155 (2006.01) C12N 15/44 (2006.01) A61P 31/16 (2006.01) (21) International Application Number: PCT/US2017/016251 (22) International Filing Date: 2 February 2017 (02.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/290,890 3 February 2016 (03.02.2016) US (71) Applicant: CG DISCOVERY, INC. [US/US]; 4838 Fair- port Way, San Diego, CA 92130 (US). (72) Inventor: LUO, Chun; c/o CG Discovery Inc., 4838 Fair- port Way, San Diego, CA 92130 (US). (74) Agents: MURASHIGE, Kate et al.; Morrison & Foerster LLP, 12531 High Bluff Drive, Suite 100, San Diego, CA 92130-2040 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, [Continued on next page] (54) Title: COMPOSITIONS OF INFLUENZA HEMAGGLUTININ WITH HETEROLOGOUS EPITOPES AND/OR ALTERED MATURATION CLEAVAGE SITES (57) Abstract: Modified forms of hemagglu- tinin (HA) protein including those with modi- fied immunodominant regions and with mod- ified maturation cleavage sites, and virus and virus-like particles containing them are dis- closed. WO 2017/136575 Al MIDEDIM01101 DIVIIMME3011110111110011111111111111011110111111 SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
Also published as:
CA3012703AU2017215345KR1020180115717US20180334479EP3411712IL260921
CN109073639BR112018015765WO/2017/136575