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1. (SG11201601138P) CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

Office : Singapore
Application Number: 11201601138P Application Date: 22.08.2014
Publication Number: 11201601138P Publication Date: 30.03.2016
Publication Kind : A1
Prior PCT appl.: Application Number:PCTUS2014052409 ; Publication Number:2015027222 Click to see the data
IPC:
A61K 31/519
C07D 471/04
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants: NEUPHARMA, INC.
Inventors: QIAN, Xiangping
ZHU, Yong-Liang
Priority Data: 61/869,596 23.08.2013 US
61/900,283 05.11.2013 US
62/000,946 20.05.2014 US
Title: (EN) CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS
Abstract:
(EN) (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 February 2015 (26.02.2015) WIPOIPCT (10) International Publication Number WO 2015/027222 A3 (51) International Patent Classification: A61K31/519 (2006.01) C07D 471/04 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2014/052409 22 August 2014 (22.08.2014) English English (30) Priority Data: 61/869,596 23 August 2013 (23.08.2013) US 61/900,283 5 November 2013 (05.11.2013) US 62/000,946 20 May 2014 (20.05.2014) US (71) Applicant: NEUPHARMA, INC. [US/US]; 1175 Chess Drive, Suite 206, Foster City, CA 94404 (US). (72) Inventors: QIAN, Xiangping; 114 Mira Street, Foster City, CA 94404 (US). ZHU, Yong-Liang; 41077 Pementel Court, Fremont, CA 94539 (US). (74) Agents: ORBAI, Lucian et al.; Wilson Sonsini Goodrich & Rosati, 650 Page Mill Road, Palo Alto, CA 94304-1050 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) (88) Date of publication of the international search report: 16 April 2015 CJ CJ CJ l> CJ © T-H O CJ o & (54) Title: CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS (57) Abstract: Chemical entities that are effective as kinase inhibitors, pharmaceutical compositions and methods of treatment are disclosed. The chemical entities disclosed specifically inhibit signal transduction and cellular proliferation by modulating the activity of protein kinases to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism. The com - pounds include a pyrido[3,2-d]pyrimidine scaffold substituted with aromatic and heteroaromatic moieties.
Also published as:
CA2921410IL244189EP3035936CN105682661KR1020160090786JP2016530274
US20170050936AU2014308616MYPI 2016000328PH1/2016/500330BR112016005199RU2016110412
IN201617005602WO/2015/027222