Processing

Please wait...

Settings

Settings

Goto Application

1. SG193998 - NOVEL CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

Office
Singapore
Application Number 2013072962
Application Date 29.03.2012
Publication Number 193998
Publication Date 29.11.2013
Publication Kind A
IPC
C07D 501/34
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14Compounds having a nitrogen atom directly attached in position 7
16with a double bond between positions 2 and 3
207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
26Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
34with the 7-amino radical acylated by carboxylic acids containing hetero rings
A61K 31/546
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and at least one sulfur as the ring hetero atoms, e.g. sulthiame
542ortho- or peri-condensed with heterocyclic ring systems
545Compounds containing 5-thia-1-azabicyclo octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine
546containing further heterocyclic rings, e.g. cephalothin
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
CPC
C07D 501/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
02Preparation
04from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
C07D 501/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14Compounds having a nitrogen atom directly attached in position 7
16with a double bond between positions 2 and 3
207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
38Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
46with the 7-amino radical acylated by carboxylic acids containing hetero rings
C07D 501/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14Compounds having a nitrogen atom directly attached in position 7
16with a double bond between positions 2 and 3
207-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
24with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
C07D 501/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
501Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula: , e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
14Compounds having a nitrogen atom directly attached in position 7
60with a double bond between positions 3 and 4
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
Applicants LEGOCHEM BIOSCIENCES, INC.
Inventors CHO, YOUNG LAG
YUN, JOUNG YUL
PARK, CHUL SOON
CHAE, SANG EUN
LEE, HYANG SOOK
OH, KYUMAN
HEO, HYE JIN
KANG, DAE HYUCK
YANG, YOUNG JAE
KWON, HYUN JIN
PARK, TAE KYO
WOO, SUNG HO
KIM, YONG ZU
Title
(EN) NOVEL CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF
Abstract
(EN) 127 [Abstract] NOVEL, CEPHALOSPORIN DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF D The present invention relates to novel cephaicaporin derivatives represented by Chemical Formula 1. W° )1144,„ ' ;. R2 (1) Wherein, X, Y, L, RI, and R2 are as same as defined in the description of the invention. 10 The bresent invent: on also reiates to pharmaceutical antibiotic compositions comprising a novel celphalosporin derivative represented by Chemical Formula I, a prbdrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, or a oharracentically acceptable salt thereof as an effective 15 ingredient. Abcording to the present invention, novel cephalosporin derivatives, a prodrug thereof, a hydrate thereof, a solvate therebf, an isomer thereof, or a pharmaceutically acceptable salt thereof as an effertive inoredient for the broad spectrum. of antibiotic resistant, low tozicity, particularly in. Gram-negative bacteria, which can be useful with strong antimicrobial activity. Figure 1