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1. (RU0002423997) COMPOSITION AND DOSAGE FORM CONTAINING SOLID OR SEMISOLID MATRIX

Office : Russian Federation
Application Number: 2008103482/15 Application Date: 22.06.2006
Publication Number: 0002423997 Publication Date: 20.07.2011
Grant Number: Grant Date: 20.07.2011
Publication Kind : C9
Prior PCT appl.: Application Number:EP2006006026 ; Publication Number:WO2007003278 Click to see the data
IPC:
A61K 9/20
A61K 47/22
A61K 8/00
A61J 3/10
A61K 47/32
A61K 31/00
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
20
Pills, lozenges or tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
06
Organic compounds
22
Heterocyclic compounds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8
Cosmetics or similar toilet preparations
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
J
CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3
Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
10
into the form of compressed tablets
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
32
Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
CPC:
A61K 9/146
A61K 9/1694
A61K 9/2013
A61K 9/2027
A61K 31/4184
A61K 31/5415
A61K 47/22
Applicants:
Inventors: РОЗЕНБЕРГ Йорг (DE)
МЭГЕРЛЯЙН Маркус (DE)
БРАЙТЕНБАХ Йорг (DE)
ROZENBERG Jorg (DE)
MEhGERLJaJN Markus (DE)
BRAJTENBAKh Jorg (DE)
Priority Data: 05014555.6 05.07.2005 EP
60/595,435 05.07.2005 US
Title: (EN) COMPOSITION AND DOSAGE FORM CONTAINING SOLID OR SEMISOLID MATRIX
(RU) КОМПОЗИЦИЯ И ЛЕКАРСТВЕННАЯ ФОРМА, СОДЕРЖАЩИЕ ТВЕРДУЮ ИЛИ ПОЛУТВЕРДУЮ МАТРИЦУ
Abstract:
(EN) FIELD: medicine, pharmaceutics. SUBSTANCE: composition for medical use contains a solid or semisolid matrix, at least one active ingredient uniformly dispersed therein. The matrix contains at least one pharmaceutically acceptable matrix-forming agent and compound 1,3-bis(lactamyl)butane, especially 1,3-bis(pyrrolidone-1-yl)butane. The active component has water-solubility less than 1 g/100 ml at 25°C. The active ingredient is preferentially dispersed in a matrix as a solid solution. The matrix-forming agent is chosen from a group of alcohol sugars, alcohol sugar derivatives, pharmaceutically acceptable polymers and their mixtures. The composition is used for preparing the pharmaceutical dosage forms for oral administration of the active ingredients. EFFECT: composition provides higher bioavailability of poorly water-soluble active ingredient due to its presence in the composition in a non-crystalline state. 19 cl, 13 ex
(RU) Композиция для медицинских целей содержит твердую или полутвердую матрицу, по меньшей мере, один равномерно диспергированный в ней активный ингредиент. Матрица содержит, по меньшей мере, один фармацевтически приемлемый образующий матрицу агент и соединение 1,3-бис(лактамил)бутана, особенно 1,3-бис(пирролидон-1-ил)бутан. Активный ингредиент имеет растворимость в воде при 25°С менее 1 г/100 мл. Активный ингредиент, предпочтительно, диспергирован в матрице в состоянии твердого раствора. Образующий матрицу агент выбран из группы сахарных спиртов, производных сахарных спиртов, фармацевтически приемлемых полимеров и их смесей. Композиция предназначена для получения фармацевтических лекарственных форм для орального введения активного ингредиента. Композиция по изобретению обеспечивает повышенную биодоступность плохо растворимого в воде активного ингредиента за счет его присутствия в композиции в некристаллическом состоянии. 4 н. и 15 з.п. ф-лы.
Also published as:
EP1898954JP2009500301US20090220596CN101217981CA2612864IN72/CHENP/2008
WO/2007/003278