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1. RU02327700 - NEW HETERO-AROMATIC INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHOTASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHOD OF INHIBITING FRUCTOSE-1,6-BISPHOSPHOTASE

Office Russian Federation
Application Number 2001109255/04
Application Date 03.09.1999
Publication Number 02327700
Publication Date 27.06.2008
Grant Number
Grant Date 27.06.2008
Publication Kind C2
IPC
C07F 9/6558
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6558containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
C07F 9/6553
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6553having sulfur atoms, with or without selenium or tellurium atoms, as the only ring hetero atoms
C07F 9/655
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
655having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
C07F 9/6509
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645having two nitrogen atoms as the only ring hetero atoms
6509Six-membered rings
C07F 9/6512
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645having two nitrogen atoms as the only ring hetero atoms
6509Six-membered rings
6512having the nitrogen atoms in positions 1 and 3
C07F 9/58
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
FACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9Compounds containing elements of Groups 5 or 15 of the Periodic System
02Phosphorus compounds
547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
553having one nitrogen atom as the only ring hetero atom
576Six-membered rings
58Pyridine rings
Inventors DANG Kvun (US)
ДАНГ Квун (US)
KASIBKhATLA Srinivas Rao (US)
КАСИБХАТЛА Сринивас Рао (US)
REDDI K. Radzha (US)
РЕДДИ К. Раджа (US)
EhRION Mark D. (US)
ЭРИОН Марк Д. (US)
REDDI M. Rami (US)
РЕДДИ М. Рами (US)
AGARVAL Atul (US)
АГАРВАЛ Атул (US)
Priority Data 09135504 22.06.1998 US
Title
(EN) NEW HETERO-AROMATIC INHIBITORS OF FRUCTOSE-1,6-BISPHOSPHOTASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND METHOD OF INHIBITING FRUCTOSE-1,6-BISPHOSPHOTASE
(RU) НОВЫЕ ГЕТЕРОАРОМАТИЧЕСКИЕ ИНГИБИТОРЫ ФРУКТОЗО-1,6-БИСФОСФАТАЗЫ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБ ИНГИБИРОВАНИЯ ФРУКТОЗО-1,6-БИСФОСФАТАЗЫ
Abstract
(EN)
FIELD: chemistry.SUBSTANCE: description is given of a hetero-aromatic compounds with a phosphonate group with formula (I) and their pharmaceutical salts, radicals of which are given in the formula of invention. The compounds are inhibitors of fructose-1,6-bisphosphotase. Description is also given of pharmaceutical compositions based on compounds with formula (I) and (X) and the method if inhibiting fructose-1,6-bisphosphotase, using the compound with formula (I).EFFECT: obtaining of new biologically active substances.184 cl, 52 tbl, 62 ex

(RU)
Описываются гетероароматические соединения с фосфонатной группой формул (I) и (X) и их фармацевтически приемлемые соли, значения радикалов которых указаны в формуле изобретения. Соединения являются ингибиторами фруктозо-1,6-бисфосфатазы. Описываются также фармацевтические композиции на основе соединений формул (I) и (X) и способ ингибирования ФБФазы, использующий соединение формулы (I). 5 н. и 179 з.п. ф-лы, 52 табл.