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1. RU02314306 - DERIVATIVES OF QUINUCLIDINEAMIDE, METHOD FOR THEIR PREPARING AND THEIR USING, PHARMACEUTICAL COMPOSITION, COMBINED PRODUCT AND METHOD FOR INHIBITION OF MUSCARINIC RECEPTORS

Office Russian Federation
Application Number 2005102585/04
Application Date 25.06.2003
Publication Number 02314306
Publication Date 10.01.2008
Grant Number
Grant Date 10.01.2008
Publication Kind C2
IPC
C07D 453/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
C07D 487/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
08Bridged systems
A61K 31/439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
439the ring forming part of a bridged ring system, e.g. quinuclidine
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
CPC
C07D 487/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
08Bridged systems
C07D 453/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
453Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
02containing not further condensed quinuclidine ring systems
Inventors PRAT-KINONES Marija (ES)
ПРАТ-КИНОНЕС Мария (ES)
Priority Data 200201539 02.07.2002 ES
Title
(EN) DERIVATIVES OF QUINUCLIDINEAMIDE, METHOD FOR THEIR PREPARING AND THEIR USING, PHARMACEUTICAL COMPOSITION, COMBINED PRODUCT AND METHOD FOR INHIBITION OF MUSCARINIC RECEPTORS
(RU) ПРОИЗВОДНЫЕ ХИНУКЛИДИНАМИДА, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, КОМБИНИРОВАННЫЙ ПРОДУКТ И СПОСОБ ИНГИБИРОВАНИЯ МУСКАРИНОВЫХ РЕЦЕПТОРОВ
Abstract
(EN)
FIELD: organic chemistry, medicine.SUBSTANCE: invention relates to novel derivatives of quinuclidineamide of the general formula (I) and their pharmaceutically acceptable salt including quaternary ammonium salts of the formula (II) wherein radicals and groups are given in the invention claim. Also, invention relates to methods for synthesis of these compounds, pharmaceutical compositions comprising indicated compounds and their using in therapy as antagonists of muscarinic receptors M3 for treatment of pathological states or diseases wherein intensity of these symptoms is decreased owing to antagonistic effect on muscarinic receptors M3.EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.27 cl, 55 ex

(RU)
Изобретение относится к новым производным хинуклидинамида общей формулы (I) и их фармацевтически приемлемым солям, включая соли четвертичного аммония формулы (II), где радикалы и группы принимают значения, указанные в формуле изобретения. Объектами изобретения также являются способы их получения, фармацевтические композиции, включая комбинированный продукт, содержащие указанные соединения, и их применение в терапии в качестве антагонистов мускариновых рецепторов М3 для лечения патологических состояний или заболеваний, интенсивность симптомов которых снижается благодаря антагонистическому воздействию на мускариновые рецепторы М3. 8 н. и 19 з.п. ф-лы.