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1. (RU02380366) PYRIDAZINYLAMINE DERIVATIVES AND USE THEREOF FOR MAKING PICORNAVIRUS INHIBITORS

Office : Russian Federation
Application Number: 2008103329/04 Application Date: 14.11.2005
Publication Number: 02380366 Publication Date: 27.01.2010
Grant Number: Grant Date: 27.01.2010
Publication Kind : C2
Prior PCT appl.: Application Number:CN2005001913 ; Publication Number: Click to see the data
IPC:
A61K 31/501
C07D 237/20
C07D 403/04
C07D 401/14
A61P 31/14
C07D 237/12
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02
not condensed with other rings
06
having three double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02
not condensed with other rings
06
having three double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12
Halogen atoms or nitro radicals
CPC:
C07D 237/20
C07D 401/04
C07D 401/12
Applicants:
Inventors: ЛИ Сун (CN)
МИ Чуньлай (CN)
ЧЖЭН Чжибин (CN)
ЧЖАО Гомин (CN)
ЧЖОУ Синьбо (CN)
ГУН Цзэхуэй (CN)
LI Sun (CN)
MI Chun'laj (CN)
ChZhEhN Chzhibin (CN)
ChZhAO Gomin (CN)
ChZhOU Sin'bo (CN)
GUN Tszehkhuehj (CN)
Priority Data: 200510081813.9 30.06.2005 CN
Title: (EN) PYRIDAZINYLAMINE DERIVATIVES AND USE THEREOF FOR MAKING PICORNAVIRUS INHIBITORS
(RU) ПРОИЗВОДНЫЕ ПИРИДАЗИНИЛАМИНА И ИХ ПРИМЕНЕНИЕ ДЛЯ ПОЛУЧЕНИЯ ИНГИБИТОРОВ ПИКОРНАВИРУСОВ
Abstract: front page image
(EN) FIELD: chemistry. SUBSTANCE: present invention relates to derivatives of substituted pyridazinylamine of formula or to their pharmaceutically acceptable salts or hydrates, where X is C or N; Y is O or S; W is C or N; R1, R2, R3 each independently represents hydrogen or halogen; R4, R5, R6 each independently represents hydrogen, halogen, C1-C8-straight or branched alkyl, C1-C8-straight or branched alkoxy, nitro, cyano, -COOR7, -CH2COOR7, -COR7; R7 independently represents hydrogen or C1-C8-straight or branched alkyl. The invention also relates to a method of producing said compounds, to pharmaceutical compositions containing said compounds and to use of the said compounds as picornavirus inhibitors for preventing and/or treating diseases caused by pircornaviruses. EFFECT: novel compounds have useful biological properties. 10 cl, 1 tbl, 33 ex
(RU) Настоящее изобретение относится к производным замещенного пиридазиниламина формулы I или к их фармацевтически приемлемым солям или гидратам, где Х представляет собой С или N; Y представляет собой О или S; W представляет собой С или N; R1, R2, R3 каждый независимо представляет собой водород или галоген; R4, R5, R6 каждый независимо представляет собой водород, галоген, C1-C8-неразветвленный или разветвленный алкил, C1-C8-неразветвленный или разветвленный алкокси, нитро, циано, - COOR7, -CH2COOR7, -COR7; R7 независимо представляет собой водород или C1-C8- неразветвленный или разветвленный алкил. Также настоящее изобретение относится к способу получения таких соединений, фармацевтическим композициям, их включающим, и к применению указанных соединений в качестве ингибиторов пикорнавирусов для профилактики и/или лечения заболеваний, вызванных пикорнавирусами. 4 н. и 6 з.п. ф-лы, 1 табл., 3 ил.
Also published as:
KR1020080045120EP1900735JP2008546814US20080269232US20110059978ES2386550
AU2005334058DK1900735IN636/DELNP/2008WO/2007/003077