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1. RU0002586333 - DERIVATIVES OF 4-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE-1-YL-UREA AND THEIR USE IN TREATMENT, INTER ALIA, DISEASES OF RESPIRATORY TRACT

Office
Russian Federation
Application Number 2014123029/04
Application Date 09.12.2011
Publication Number 0002586333
Publication Date 10.06.2016
Grant Number
Grant Date 10.06.2016
Publication Kind C1
IPC
A61K 31/5375
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
535having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
53751,4-Oxazines, e.g. morpholine
C07D 471/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
A61K 31/4196
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41961,2,4-Triazoles
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
A61K 31/4439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
Inventors ФИНЧ Гарри (IT)
ВАН НИЛ Моник Бодил (IT)
ВУ Чи-Кит (IT)
FINCH Harry (IT)
VAN NIEL Monique Bodil (IT)
WOO Chi-Kit (IT)
Title
(EN) DERIVATIVES OF 4-HYDROXY-1,2,3,4-TETRAHYDRONAPHTHALENE-1-YL-UREA AND THEIR USE IN TREATMENT, INTER ALIA, DISEASES OF RESPIRATORY TRACT
(RU) ПРОИЗВОДНЫЕ 4-ГИДРОКСИ-1,2,3,4-ТЕТРАГИДРОНАФТАЛИН-1-ИЛ-МОЧЕВИНЫ И ИХ ПРИМЕНЕНИЕ В ЛЕЧЕНИИ, СРЕДИ ПРОЧЕГО, ЗАБОЛЕВАНИЙ ДЫХАТЕЛЬНОГО ТРАКТА
Abstract
(EN) FIELD: chemistry. SUBSTANCE: invention relates to individual compounds comprising 4-hydroxy-1,2,3,4-tetrahydronaphthalene-1-yl-urea, and pharmaceutically acceptable salts thereof. Compounds of invention have properties of inhibitor of p38 MAP kinase. Invention also relates to pharmaceutical composition, to method for inhibiting p38 MAP kinase and to use of compounds in manufacture of medicament. EFFECT: Technical result provided new compounds having properties of inhibitor of p38 MAP kinase, which are useful as anti-inflammatory agents in treatment of diseases of respiratory tract. 9 cl, 3 tbl, 34 ex
(RU) Изобретение относится к индивидуальным соединениям, содержащим 4-гидрокси-1,2,3,4-тетрагидронафталин-1-ил-мочевину, и их фармацевтически приемлемым солям. Соединения изобретения обладают свойствами ингибитора активности МАР-киназы р38. Изобретение также относится к фармацевтической композиции, к способу ингибирования активности МАР-киназы р38 и к применению соединений в изготовлении лекарственного средства. Технический результат: получены новые соединения, обладающие свойствами ингибитора активности МАР-киназы р38, которые могут применяться в качестве противовоспалительных агентов в лечении заболеваний дыхательного тракта. 4 н. и 5 з.п. ф-лы, 3 табл., 34 пр.
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