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1. RU0002565079 - BENZAMIDE DERIVATIVES HAVING ANTICANCER ACTIVITY, METHODS FOR PRODUCTION THEREOF AND USE THEREOF

Office Russian Federation
Application Number 2013125721/04
Application Date 03.11.2011
Publication Number 0002565079
Publication Date 20.10.2015
Grant Number
Grant Date 20.10.2015
Publication Kind C2
IPC
C07C 233/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
90having nitrogen atoms of carboxamide groups further acylated
92with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 269/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
269Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
04from amines with formation of carbamate groups
C07C 271/64
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
271Derivatives of carbamic acid, i.e. compounds containing any of the groups the nitrogen atom not being part of nitro or nitroso groups
62Compounds containing any of the groups X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
64Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 255/57
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
57containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
C07C 231/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
02from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
CPC
C07C 255/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
58containing cyano groups and singly-bound nitrogen atoms, not being further bound to other hetero atoms, bound to the carbon skeleton
60at least one of the singly-bound nitrogen atoms being acylated
C07C 231/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
231Preparation of carboxylic acid amides
02from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
C07C 233/65
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
64having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
65having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
C07C 233/92
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
233Carboxylic acid amides
90having nitrogen atoms of carboxamide groups further acylated
92with at least one carbon atom of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
C07C 253/30
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
253Preparation of carboxylic acid nitriles
30by reactions not involving the formation of cyano groups
C07C 255/57
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
255Carboxylic acid nitriles
49having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
57containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
Inventors БАЙ Хуа (CN)
ЧЖАО Сюйян (CN)
ГУН Юнсян (CN)
ЧЖУН Цзиньцин (CN)
ЧЖУ Цифэн (CN)
ЛЮ Сяоюй (CN)
ЛЮ Лифэй (CN)
ЧЖОУ Цисянь (CN)
BAJ Khua (CN)
ChZhAO Sjujjan (CN)
GUN Junsjan (CN)
ChZhUN Tszin'tsin (CN)
ChZhU Tsifehn (CN)
LJu Sjaojuj (CN)
LJu Lifehj (CN)
ChZhOU Tsisjan' (CN)
Priority Data 201010532658.9 05.11.2010 CN
Title
(EN) BENZAMIDE DERIVATIVES HAVING ANTICANCER ACTIVITY, METHODS FOR PRODUCTION THEREOF AND USE THEREOF
(RU) БЕНЗАМИДНЫЕ ПРОИЗВОДНЫЕ, ОБЛАДАЮЩИЕ ПРОТИВОРАКОВОЙ АКТИВНОСТЬЮ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИХ ПРИМЕНЕНИЕ
Abstract
(EN)
FIELD: chemistry. SUBSTANCE: invention relates to a compound of formula (I), or a pharmaceutically acceptable salt thereof, where R1 and R2 are independently selected from a group consisting of hydrogen, unsubstituted (C1-C8)alkyl, -COR5 and -CO2R6; R1 and R2 can also be cyclised to form a substituted or unsubstituted 4-, 5- or 6-member ring, selected from morpholine, piperidine, pyrrolidine, piperazine, azetidine, 4-methylpiperazine; R3 is nitro or nitroso; R4 is selected from a group consisting of ethynyl, propynyl or cyano; R5 is selected from a group consisting of an unsubstituted (C1-C8)alkyl or unsubstituted aryl; R6 is unsubstituted (C1-C8)alkyl. The invention also relates to methods of producing the compound of formula (I) (versions). The compounds of formula (I) are intended for preparing a pharmaceutical composition or a medicinal agent for treating a disease associated with a poly (ADP-ribose) polymerase (PARP) inhibitor, or for treating cancer, which contains an effective dose of a compound of formula (I) or a pharmaceutically acceptable salt thereof. EFFECT: benzamide derivatives intended for producing a medicinal agent for treating a disease associated with a poly (ADP-ribose) polymerase (PARP) inhibitor, or cancer. 20 cl, 2 tbl, 37 ex

(RU)
Изобретение относится к соединению, представленному формулой (I), или его фармацевтически приемлемой соли, где R1 и R2 независимо выбраны из группы, состоящей из водорода, незамещенного (C1-C8)алкила, -COR5 и -CO2R6; R1 и R2 также могут циклизоваться с образованием замещенного или незамещенного 4-, 5- или 6-членного кольца, выбранного из морфолина, пиперидина, пирролидина, пиперазина, азетидина, 4-метилпиперазина; R3 представляет собой нитро или нитрозо; R4 выбран из группы, состоящей из этинила, пропинила или циано; R5 выбран из группы, состоящей из незамещенного (C1-C8)алкила или незамещенного арила; R6 представляет собой незамещенный (C1-C8)алкил. Также изобретение относится к способам получения соединения формулы (I) (вариантам). Соединения формулы (I) предназначены для изготовления фармацевтической композиции или лекарственного средства для лечения заболевания, связанного с ингибитором поли(АДФ-рибоза)-полимеразы (PARP), или для лечения рака, содержащей эффективную дозу соединения формулы (I) или его фармацевтически приемлемой соли. Технический результат - производные бензамида, предназначенные для получения лекарственного средства для лечения заболевания, связанного с ингибитором поли(АДФ-рибоза)-полимеразы (PARP), или рака. 9 н. и 11 з.п. ф-лы, 2 табл., 37 пр.