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1. RU0002560257 - ANTI-c-Met ANTIBODY

Office
Russian Federation
Application Number 2011124751/10
Application Date 02.12.2009
Publication Number 0002560257
Publication Date 20.08.2015
Grant Number
Grant Date 20.08.2015
Publication Kind C2
IPC
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
C07K 16/40
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
40against enzymes
A61K2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/2863
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2863against receptors for growth factors, growth regulators
C07K2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K2317/53
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
53Hinge
Inventors ГЁТШ, Лилиан (FR)
ВЮРШ, Тьерри (FR)
БЕС, Седрик (FR)
GETSh, Lilian (FR)
VJuRSh, T'erri (FR)
BES, Sedrik (FR)
Priority Data PCT/IB2008/055663 02.12.2008 IB
61/184,502 05.06.2009 US
Title
(EN) ANTI-c-Met ANTIBODY
(RU) АНТИТЕЛО ПРОТИВ c-Met
Abstract
(EN) FIELD: chemistry. SUBSTANCE: invention refers to biochemistry. There are described an antibody specifically binding to a human c-Met receptor and/or specifically inhibiting tyrosine kinase activity, containing a modified 'link' region of this receptor with an improved antagonist activity, containing the modified 'link' region, and a composition containing this anti-c-Met antagonist antibody and using it as a drug for cancer. There are described a nucleic acid coding this antibody, an expression vector containing the above nucleic acid, as well as a host cell containing the above vector. EFFECT: invention extends the range of products for diagnosing diseases induced by hyperexpression or reduced expression of the c-Met receptor. 28 cl, 35 dwg, 4 tbl, 18 ex
(RU) Изобретение относится к биохимии. Описаны антитело, способное к специфичному связыванию с рецептором c-Met человека и/или способное к специфичному ингибированию тирозинкиназной активности этого рецептора, с улучшенной антагонистической активностью, содержащее модифицированную шарнирную область, и композиция, содержащая такое антагонистическое антитело к c-Met, и его применение в качестве лекарства для лечения рака. Описаны нуклеиновая кислота, кодирующая данное антитело, вектор экспрессии, содержащий описанную нуклеиновую кислоту, также клетка-хозяин, содержащая данный вектор. Изобретение расширяет арсенал средств диагностики заболеваний, индуцированных гиперэкспрессией или сниженной экспрессией рецептора c-Met. 11 н. и 17 з.п. ф-лы, 35 ил., 4 табл., 18 пр.
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