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1. PT892636 - SOLUCOESOFTALMICAS TORNADAS VISCOSAS COM POLISSACARIDO DE SEMENTE DE TAMARINDO

Office
Portugal
Application Number 97902574
Application Date 04.02.1997
Publication Number 892636
Publication Date 28.02.2002
Publication Kind E
IPC
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
CPC
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
A61K 47/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
Applicants FARMIGEA SPA
Inventors BIANCHINI PIETRO
SAETTONE MARCO FABRIZIO
GIANNACCINI BORIS
BURGALASSI SUSI
BOLDRINI ENRICO
LUCIANI GIULIO
Title
(PT) SOLUCOESOFTALMICAS TORNADAS VISCOSAS COM POLISSACARIDO DE SEMENTE DE TAMARINDO
Abstract
(EN)
The polysaccharide fraction of tamarind gum, a product of natural origin obtained from the seeds of $i(Tamarindus indica), is used for the production of a thickened ophthalmic solution having a pseudoplastic rheological behaviour and mucoadhesive properties. Said solution is useful as artificial tear and as vehicle for sustained release ophthalmic drugs. The concentrations of tamarind seed polysaccharide preferably employed in ophthalmic preparations for use as artificial tears, i.e. as products for replacing and stabilising the natural tear fluid, particularly indicated for the treatment of dry eye syndrome, are comprised between 0.7 and 1.5 % by weight. The concentrations of tamarind seed polysaccharide preferably employed in the production of vehicles (i.e. delivery systems) for ophthalmic drugs, having the function of prolonging the permanence time of said medicaments at their site of action, are comprised between 1 and 4 % by weight.

(FR)
La fraction polysaccharide de la gomme de tamarin, un produit naturel obtenu des graines de $i(Tamarindus indica), est utilisée dans la production d'une solution ophtalmique épaissie présentant un comportement rhéologique du type pseudoplastique et des propriétés muco-adhésives. Ladite solution est utile comme larmes artificielles et comme excipient pour des médicaments ophtalmiques à libération prolongée. Les concentrations de polysaccharide de graines de tamarin utilisées de préférence dans des préparations ophtalmiques destinées à être utilisées comme larmes artificielles, c'est-à-dire comme produits destinés à remplacer et à stabiliser le liquide lacrymal naturel, particulièrement indiqués pour le traitement du syndrome de l'oeil sec, sont comprises entre 0,7 et 1,5 % en poids. Les concentrations de polysaccharide de graines de tamarin de préférence utilisées dans la production d'excipients (c'est-à-dire des systèmes de libération) pour médicaments ophtalmiques, et dont la fonction est de prolonger le temps de séjour desdits médicaments au niveau de leur site d'action, sont comprises entre 1 et 4 % en poids.