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1. PH1/2011/500928 - ANTI-CMET ANTIBODY

Office
Philippines
Application Number 1/2011/500928
Application Date 02.12.2009
Publication Number 1/2011/500928
Publication Date 19.08.2016
Publication Kind A
IPC
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants PIERRE FABRE MEDICAMENT
Inventors WURCH, Thierry
GOETSCH, Liliane
BES, C├ędric
Agents ROMULO MABANTA BUENAVENTURA SAYOC AND DELOS ANGELES
Title
(EN) ANTI-CMET ANTIBODY
Abstract
(EN) Antibodies capable of binding specifically to the human c-Met receptor and/or capable of inhibiting the tyrosine kinase activity of said receptor, with an improved antagonistic activity, antibodies comprising a modified hinge region. A composition comprising one or more of such an antibodies antagonist to c-Met and its use as a medicament for treating cancer.
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