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1. PE2012-0343 - ANTICUERPO ANTI-CMET QUE COMPRENDE UNA REGION BISAGRA

Office
Peru
Application Number 2011001117
Application Date 02.12.2009
Publication Number 2012-0343
Publication Date 16.04.2012
Publication Kind A1
IPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C07K 16/46
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
46Hybrid immunoglobulins
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/2863
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2863against receptors for growth factors, growth regulators
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/53
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
52Constant or Fc region; Isotype
53Hinge
C07K 2317/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
Applicants PIERRE FABRE MEDICAMENT
Inventors LILIANEGOETSCH
THIERRYWURCH
CEDRICBES
Title
(ES) ANTICUERPO ANTI-CMET QUE COMPRENDE UNA REGION BISAGRA
Abstract
(ES) REFERIDA A UN ANTICUERPO MONOCLONAL, O SU FRAGMENTO O DERIVADO FUNCIONAL DIVALENTE, CAPAZ DE INHIBIR LA DIMERIZACION DE c-MET, QUE COMPRENDE: A) UNA CADENA PESADA QUE COMPRENDE CDR-H1 (SEC ID NO:1), CDR-H2 (SEC ID NO:2), CDR-H3 (SEC ID NO: 3); B) UNA CADENA LIGERA QUE COMPRENDE CDR-L1 (SEC ID NO: 5), CDR-L2 (SEC ID NO:6), CDR-L3 (SEC ID:7); Y C) UNA REGION BISAGRA QUE COMPRENDE LAS SECUENCIAS DE AMINOACIODS SELECCIONADA DE SEC ID NO: 22 A 28 Y SEC ID NO:72 A 86. DICHO ANTICUERPO SE UNE ESPECIFICAMENTE AL RECEPTOR C-MET HUMANO, INHIBIENDO ESPECIFICAMENTE LA ACTIVIDAD DE TIROSINA QUINASA DE DICHO RECEPTOR SIENDO UTIL EN EL TRATAMIENTO DE CANCER Y CUALQUIER PATOLOGIA RELACIONADA CON LA SOBREEXPRESION DE DICHO RECEPTOR
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