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1. PE2008-0373 - FORMULACIONES DE ALISQUIRENO E HIDROCLOROTIAZIDA

Office Peru
Application Number 2007000804
Application Date 22.06.2007
Publication Number 2008-0373
Publication Date 06.06.2008
Publication Kind A1
IPC
A61K 9/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 31/165
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
CPC
A61K 9/2018
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2013Organic compounds, e.g. phospholipids, fats
2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
A61K 9/2077
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2072characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
A61K 9/2095
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
A61K 31/165
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
165having aromatic rings, e.g. colchicine, atenolol, progabide
A61K 31/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
54having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
549having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
Applicants NOVARTIS AG
Inventors MATTHIAS WILLMANN
Agents ESTUDIO COLMENARES S.R.L.
Priority Data 0612540.5 23.06.2006 GB
Title
(ES) FORMULACIONES DE ALISQUIRENO E HIDROCLOROTIAZIDA
Abstract
(ES)
REFERIDA A UNA FORMA DE DOSIFICACION ORAL SOLIDA QUE COMPRENDE a) UN INHIBIDOR DE RENINA TAL COMO ALISQUIRENO (2(S),4(S),5(S),7(S)-N-(3-AMINO-2,2-DIMETIL-3-OXO-PROPIL)-2,7-DI-(1-METIL-ETIL)-4-HIDROXI-5-AMINO-8-[4-METOXI-3-(3-METOXI-PROPOXI)-FENIL]OCTANAMIDA) O UNA SAL DEL MISMO, b) HIDROCLOROTIAZIDA (HCTZ) Y c) UN RELLENO HIDROFILICO TAL COMO DEXTRINA, DEXTROSA, LACTOSA, MANITOL, SORBITOL, ENTRE OTROS; DONDE EL ALISQUIRENO SE ENCUENTRA EN UNA CANTIDAD DE ENTRE 25% AL 47% EN PESO EN BASE AL PESO TOTAL DE LA FORMULACION, LA HIDROCLOROTIAZIDA SE ENCUENTRA EN UNA CANTIDAD DE ENTRE 0,5% A 10% EN PESO Y EL COMPONENTE c) SE ENCUENTRA EN UNA CANTIDAD DE ENTRE EL 3% A 30% EN PESO. TAMBIEN PUEDE CONTENER UN DESINTEGRANTE TAL COMO POLIVINILPIRROLIDONA; UN LUBRICANTE TAL COMO ESTEARATO DE MAGNESIO, TALCO, ENTRE OTROS; UN DERRAPANTE TAL COMO TRISILICATO DE MAGNESIO, SILICE COLOIDAL, CELULOSA EN POLVO, ENTRE OTROS.