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1. PE2008-0207 - DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS COMO INHIBIDORES DEL CANAL DE POTASIO Kv1.5

Office Peru
Application Number 2007000778
Application Date 19.06.2007
Publication Number 2008-0207
Publication Date 08.05.2008
Publication Kind A1
IPC
A61K 31/438
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
438the ring being spiro-condensed with carbocyclic or heterocyclic ring systems
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
CPC
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
A61P 9/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
A61P 9/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
06Antiarrhythmics
A61P 25/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
04Centrally acting analgesics, e.g. opioids
C07D 471/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
Applicants WYETH
Inventors JOHN MICHAEL JANUSZ
SHENGDE WU
NEIL T. FAIRWEATHER
WENLIN LEE
BENJAMIN E. BLASS
ANDREW J. FLUXE
STEPHEN J. HODSON
JAMES M. RIDGEWAY II
Agents ESTUDIO COLMENARES S.R.L.
Priority Data 60/815,066 20.06.2006 US
Title
(ES) DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS COMO INHIBIDORES DEL CANAL DE POTASIO Kv1.5
Abstract
(ES)
SE REFIERE A COMPUESTOS DERIVADOS DE 1-N-AMINO-2-IMIDAZOLIDINONAS DE FORMULA (I) DONDE R ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, HALOALQUILO(C1-C6), CN, NO2, ENTRE OTROS; R1 ES FENILO OPCIONALMENTE SUSTITUIDO CON HALOGENO, ALQUILO(C1-C6), CN, NO2, ENTRE OTROS; R2 ES ALQUILO(C1-C6), CICLOALQUILO(C3-C6) O C(O)R23, DONDE R23 ES ALQUILO(C1-C6) O CICLOALQUILO(C3-C6); R3 ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS; L, L1 Y L2 SON CADA UNO [C(R19)2]n, DONDE R19 ES H, METILO O ETILO; n ES DE 1 A 4; x, y Y z SON CADA UNO 0 O 1. SON COMPUESTOS PREFERIDOS: 2-(4-CICLOPROPILFENIL)-3-[2-(4-METOXIFENIL)ETIL]-1-METIL-1,3,8-TRIAZAESPIRO[4.5]DECAN-4-ONA, 2-(4-TERC-BUTILFENIL)-3-[2-(4-METOXIFENIL)ETIL]-1-METIL-1,3,8-TRIAZAESPIRO[4.5]DECAN-4-ONA, 2-(4-DIFLUOROMETOXIFENIL)-3-[2-(4-METOXIFENIL)ETIL]-1-METIL-1,3,8-TRIAZAESPIRO[4.5]DECAN-4-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DEL CANAL DE POTASIO Kv1.5 SIENDO UTILES EN EL TRATAMIENTO DE ARRITMIA, INSUFICIENCIA CARDIACA