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1. WO2017173358 - OXYSTEROLS AND METHODS OF USE THEREOF

Publication Number WO/2017/173358
Publication Date 05.10.2017
International Application No. PCT/US2017/025535
International Filing Date 31.03.2017
IPC
A61K 31/56 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
C07J 1/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
1Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
CPC
A61K 31/575
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
575substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
A61K 31/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
58containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
20Hypnotics; Sedatives
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
Applicants
  • SAGE THERAPEUTICS, INC. [US]/[US]
Inventors
  • ROBICHAUD, Albert, Jean
  • SALITURO, Francesco, G.
  • MARTINEZBOTELLA, Gabriel
  • HARRISON, Boyd, L.
  • REID, John, Gregory
Agents
  • MCCARTY, Catherine, M.
  • BRODOWSKI, Michael
  • ARGENTIERI, Steven, R.
  • ASHRAF, Shovon
  • BUCHMAN, Joshua
Priority Data
62/317,00201.04.2016US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) OXYSTEROLS AND METHODS OF USE THEREOF
(FR) OXYSTÉROLS ET LEURS MÉTHODES D'UTILISATION
Abstract
(EN) Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R1, and R5 are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.
(FR) L'invention porte sur des composés selon la formule (I) et sur des sels pharmaceutiquement acceptables de ceux-ci, ainsi que sur des compositions pharmaceutiques associées. Dans la formule (I), A, R1, et R5 sont tels que définis dans la description. Les composés selon la présente invention s'avèrent utiles pour prévenir et traiter divers états.
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