WO2017173358 OXYSTEROLS AND METHODS OF USE THEREOF

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Publication Number WO/2017/173358

Publication Date 05.10.2017

International Application No. PCT/US2017/025535

International Filing Date 31.03.2017

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CPC

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Applicants

SAGE THERAPEUTICS, INC. [US]/[US]

Inventors

ROBICHAUD, Albert, Jean
SALITURO, Francesco, G.
MARTINEZBOTELLA, Gabriel
HARRISON, Boyd, L.
REID, John, Gregory

Agents

MCCARTY, Catherine, M.
BRODOWSKI, Michael
ARGENTIERI, Steven, R.
ASHRAF, Shovon
BUCHMAN, Joshua

Priority Data

62/317,002

01.04.2016

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) OXYSTEROLS AND METHODS OF USE THEREOF

(FR) OXYSTÉROLS ET LEURS MÉTHODES D'UTILISATION

Abstract

(EN) Compounds are provided according to Formula (I), and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof; wherein A, R¹, and R⁵ are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of conditions.

(FR) L'invention porte sur des composés selon la formule (I) et sur des sels pharmaceutiquement acceptables de ceux-ci, ainsi que sur des compositions pharmaceutiques associées. Dans la formule (I), A, R¹, et R⁵ sont tels que définis dans la description. Les composés selon la présente invention s'avèrent utiles pour prévenir et traiter divers états.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
56	Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
1	Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
56	Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
J	STEROIDS
1	Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
56	Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
575	substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol

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1. WO2017173358 - OXYSTEROLS AND METHODS OF USE THEREOF

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1	Drugs for disorders of the alimentary tract or the digestive system