WO2017091818 COMT INHIBITING METHODS AND COMPOSITIONS

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Publication Number WO/2017/091818

Publication Date 01.06.2017

International Application No. PCT/US2016/063779

International Filing Date 25.11.2016

IPC

CPC

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Applicants

LIEBER INSTITUTE FOR BRAIN DEVELOPMENT [US]/[US]

Inventors

BARROW, James
ERNST, Glen
SWINNEN, Dominique
MONTEL, Florian
DEFAYS, Sabine
HUANG, Yifang
DE LÉON, Pablo
POSLUSNEY, Michael Steven

Agents

SONNENFELD, Kenneth H.

Priority Data

62/260,067

25.11.2015

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) COMT INHIBITING METHODS AND COMPOSITIONS

(FR) MÉTHODES ET COMPOSITIONS D'INHIBITION DE COMT

Abstract

(EN) Compounds that inhibit COMT enzyme and pharmaceutical compositions comprising the same are provided herein. Methods of treating various psychiatric and neurological disorders with the compounds and pharmaceutical compositions described herein are also provided.

(FR) L'invention concerne des composés qui inhibent l'enzyme COMT et des compositions pharmaceutiques les comprenant. L'invention concerne également des méthodes de traitement de divers troubles psychiatriques et neurologiques avec les composés et compositions pharmaceutiques de l'invention.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
471	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9	Compounds containing elements of Groups 5 or 15 of the Periodic System
02	Phosphorus compounds
547	Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6561	containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
D	HETEROCYCLIC COMPOUNDS
471	Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02	in which the condensed system contains two hetero rings
04	Ortho-condensed systems

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9	Compounds containing elements of Groups 5 or 15 of the Periodic System
02	Phosphorus compounds
547	Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6561	containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
165	having aromatic rings, e.g. colchicine, atenolol, progabide

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1. WO2017091818 - COMT INHIBITING METHODS AND COMPOSITIONS

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
185	Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19	Carboxylic acids, e.g. valproic acid
195	having an amino group
197	the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
185	Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19	Carboxylic acids, e.g. valproic acid
195	having an amino group
197	the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid