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1. WO2017040932 - HUMANIZED ANTI-CD40 ANTIBODIES AND USES THEREOF

Publication Number WO/2017/040932
Publication Date 09.03.2017
International Application No. PCT/US2016/050114
International Filing Date 02.09.2016
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
C07K 16/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 31/436
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
4353ortho- or peri-condensed with heterocyclic ring systems
436the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 39/39558
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
39558against tumor tissues, cells, antigens
Applicants
  • PRIMATOPE THERAPEUTICS INC. [US]/[US]
Inventors
  • YU, Bo
  • WANG, Rijian
  • REIMANN, Keith
Agents
  • DAVITZ, Michael, A.
  • ELLIS, Edward, J.
  • KRAMER CARNEY, Bonnie
  • LEASON, David
  • CHENG, Susie
Priority Data
62/214,41104.09.2015US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMANIZED ANTI-CD40 ANTIBODIES AND USES THEREOF
(FR) ANTICORPS HUMANISÉS ANTI-CD40 ET LEURS UTILISATIONS
Abstract
(EN)
The present disclosure relates to anti-CD40 antibodies, such as humanized anti-CD-40 antibodies, that may be used in various therapeutic, prophylactic and diagnostic methods. The antibodies generally block the ability of CD40 to bind CD154 and do so without activating the cell expressing CD40 (e.g., a B cell). The present antibodies or fragments thereof may be used to reduce complications associated with organ or tissue transplantation.
(FR)
La présente invention concerne des anticorps anti-CD40, tels que des anticorps humanisés anti-CD-40, qui peuvent être utilisés dans divers procédés thérapeutiques, prophylactiques et diagnostiques. Les anticorps bloquent généralement la capacité du CD40 à se lier au CD154, et ce sans activer la cellule exprimant le CD40 (par exemple, un lymphocyte B). Les anticorps ou les fragments de ceux-ci selon la présente invention peuvent être utilisés pour réduire les complications associées à une greffe d'organe ou de tissu.
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