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1. WO2013003625 - ANTIBODIES TO ADP-RIBOSYL CYCLASE 2

Publication Number WO/2013/003625
Publication Date 03.01.2013
International Application No. PCT/US2012/044703
International Filing Date 28.06.2012
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 47/6871
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6871the antibody targeting an enzyme
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 11/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
06Antiasthmatics
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
Applicants
  • OXFORD BIOTHERAPEUTICS LTD. [GB]/[GB] (AllExceptUS)
  • ROHLFF, Christian [DE]/[GB] (UsOnly)
  • TERRETT, Jonathan, Alexander [GB]/[US] (UsOnly)
Inventors
  • ROHLFF, Christian
  • TERRETT, Jonathan, Alexander
Agents
  • REMILLARD, Jane, E.
Priority Data
61/502,16728.06.2011US
PCT/US2012/04445127.06.2012US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODIES TO ADP-RIBOSYL CYCLASE 2
(FR) ANTICORPS
Abstract
(EN) The invention provides antibodies which bind to the ADP-ribosyl cyclase 2. Nucleic acid molecules encoding the antibodies, expression vectors, host cells and methods for expressing the antibodies are also provided. The antibodies may be used for the treatment of human cancers, including acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer and pancreatic cancer and human inflammatory diseases, including asthma, gout, crohns, lupus, multiple sclerosis, rheumatoid arthritis, psoriasis, diabetes and atherosclerotic.
(FR) L'invention concerne des anticorps qui se fixent à la ADP-ribosyl cyclase 2. Des molécules d'acide nucléique codant pour les anticorps, des vecteurs d'expression, des cellules hôtes et des méthodes d'expression des anticorps sont également divulgués. Lesdits anticorps peuvent être utilisés pour le traitement de cancers humains, dont la leucémie myéloïde aiguë (LMA), la leucémie lymphoïde à lymphocytes B chronique, le cancer du sein, le cancer colorectal, le cancer du rein, le cancer de la tête et du cou, le cancer de la langue, le cancer de l'ovaire et les maladies inflammatoires humaines dont l'asthme, la goutte, la maladie de Crohn, le lupus, la sclérose en plaques, la polyarthrite rhumatoïde, le psoriasis le diabète et l'athérosclérose.
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