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1. WO2012167143 - ANTIBODIES SPECIFIC FOR TGF-BETA

Publication Number WO/2012/167143
Publication Date 06.12.2012
International Application No. PCT/US2012/040545
International Filing Date 01.06.2012
IPC
C07K 16/22 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
22against growth factors
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
04for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
A61P 1/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
A61P 1/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
16for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
Applicants
  • XOMA TECHNOLOGY LTD. (AllExceptUS)
  • BEDINGER, Daniel [US]/[US] (UsOnly)
  • KHAN, Shireen, S. [US]/[US] (UsOnly)
  • MIRZA, Amer [US]/[US] (UsOnly)
  • NARASIMHA, Ajay, J. [US]/[US] (UsOnly)
  • TAKEUCHI, Toshihiko [US]/[US] (UsOnly)
Inventors
  • BEDINGER, Daniel
  • KHAN, Shireen, S.
  • MIRZA, Amer
  • NARASIMHA, Ajay, J.
  • TAKEUCHI, Toshihiko
Agents
  • NEVILLE, Katherine, L.
Priority Data
61/493,23003.06.2011US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODIES SPECIFIC FOR TGF-BETA
(FR) ANTICORPS SPÉCIFIQUES DU TGF BÊTA
Abstract
(EN) The present disclosure relates, in general, to materials and methods for antibodies specific for transforming growth factor beta (TGFPβ), including TGFβ1, TGFβ2 and TGFβ3, and uses of these antibodies in the treatment of subjects having cancer, an eye disease, condition or disorder, fibrosis, including ophthalmic fibrosis or fibrosis of the eye, and other conditions or disorders related to TGFβ expression.
(FR) La présente invention concerne, d'une façon générale, d'une part des substances et des procédés destinés à des anticorps spécifiques du facteur de croissance transformant bêta ou "TGFPβ", et notamment les TGFβ1, TGFβ2 et TGFβ3, et d'autre part les utilisations de ces anticorps dans le traitement de sujets souffrant de cancer, d'une maladie des yeux, d'un état ou d'un trouble oculaire, de fibrose, y compris la fibrose ophtalmique ou la fibrose de l'œil, et d'autres états ou troubles se rapportant à l'expression des TGFβ.
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