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1. WO2010080486 - METHOD FOR CONTROLLING STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A POLYSACCHARIDE MOLECULAR WEIGHT

Publication Number WO/2010/080486
Publication Date 15.07.2010
International Application No. PCT/US2009/068429
International Filing Date 17.12.2009
IPC
C12P 19/04 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
CPC
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof
20Bacteria
C12P 19/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Applicants
  • WYETH LLC [US]/[US] (AllExceptUS)
  • CRINEAN, Jean Heather [US]/[US] (UsOnly)
Inventors
  • CRINEAN, Jean Heather
Agents
  • ZAHNER, Joseph, E.
Priority Data
61/138,56318.12.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR CONTROLLING STREPTOCOCCUS PNEUMONIAE SEROTYPE 19A POLYSACCHARIDE MOLECULAR WEIGHT
(FR) PROCÉDÉ DE RÉGULATION DE LA MASSE MOLÉCULAIRE DE POLYSACCHARIDE DE SÉROTYPE 19A DE STREPTOCOCCUS PNEUMONIAE
Abstract
(EN) The present invention provides improved methods for producing a solution containing high molecular weight isolated Streptococcus pneumoniae 19A capsular polysaccharides. In certain methods, a fermentation culture of Streptococcus pneumoniae bacterial cells that produce serotype 19A capsular polysaccharides is fermented for less than 6 hours before the bacterial cells are lysed the capsular polysaccharides are harvested. In other methods, CO2 is supplied to the fermentation culture. Supplying CO2 to the fermentation culture includes adding bicarbonate ions to the fermentation culture, adding carbonate ions to the fermentation culture, adding mixtures of bicarbonate and carbonate ions to the fermentation culture, and overlaying the fermentation culture with CO2.
(FR) La présente invention porte sur des procédés améliorés de production d'une solution contenant des polysaccharides capsulaires 19A de Streptococcus pneumoniae isolés à masse moléculaire élevée. Dans certains procédés, une culture de fermentation de cellules bactériennes de Streptococcus pneumoniae qui produisent des polysaccharides capsulaires de sérotype 19A est fermentée pendant moins de 6 heures avant que les cellules bactériennes soient lysées et que les polysaccharides capsulaires soient récoltés. Dans d'autres procédés, du CO2 est fourni à la culture de fermentation. L'apport de CO2 à la culture de fermentation comprend l'ajout d'ions bicarbonate à la culture de fermentation, l'ajout d'ions carbonate à la culture de fermentation, l'ajout de mélanges d'ions bicarbonate et carbonate à la culture de fermentation et le recouvrement de la culture de fermentation par du CO2.
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