Processing

Please wait...

Settings

Settings

Goto Application

1. WO2010080484 - METHOD FOR CONTROLLING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE MOLECULAR WEIGHT USING CARBON

Publication Number WO/2010/080484
Publication Date 15.07.2010
International Application No. PCT/US2009/068424
International Filing Date 17.12.2009
IPC
C12N 1/20 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
20Bacteria; Culture media therefor
C12P 19/04 2006.1
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
A61K 39/09 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
09Streptococcus
C08B 37/00 2006.1
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
BPOLYSACCHARIDES; DERIVATIVES THEREOF
37Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
CPC
A61K 39/092
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
02Bacterial antigens
09Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus; , streptococcus
092Streptococcus
C08L 2203/02
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
2203Applications
02for biomedical use
C08L 5/00
CCHEMISTRY; METALLURGY
08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
LCOMPOSITIONS OF MACROMOLECULAR COMPOUNDS
5Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
C12N 1/20
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1Microorganisms, e.g. protozoa; Compositions thereof
20Bacteria
C12P 19/04
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
19Preparation of compounds containing saccharide radicals
04Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
Applicants
  • WYETH LLC [US]/[US] (AllExceptUS)
  • CRINEAN, Jean, Heather [US]/[US] (UsOnly)
Inventors
  • CRINEAN, Jean, Heather
Agents
  • ZAHNER, Joseph, E.
Priority Data
61/138,57018.12.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR CONTROLLING STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE MOLECULAR WEIGHT USING CARBON
(FR) PROCÉDÉ DE CONTRÔLE DU POIDS MOLÉCULAIRE D'UN POLYSACCHARIDE PROVENANT DE STREPTOCOCCUS PNEUMONIAE EN UTILISANT DU CARBONE
Abstract
(EN) The present invention provides improved methods for producing a solution containing high molecular weight isolated Streptococcus pneumoniae capsular polysaccharides having phosphodiester linkages between saccharide repeat units. In certain methods, CO2 is supplied to a fermentation culture of Streptococcus pneumoniae bacterial cells that produce capsular polysaccharide serotypes containing phosphodiester linkages between saccharide repeat units. Exemplary Streptococcus pneumoniae serotypes containing a phosphodiester linkage between saccharide repeat units include serotypes 6A, 6B, 19A, and 19F. Supplying CO2 to the fermentation culture includes adding bicarbonate ions to the fermentation culture, adding carbonate ions to the fermentation culture, adding mixtures of bicarbonate and carbonate ions to the fermentation culture, and overlaying the fermentation culture with CO2.
(FR) La présente invention concerne des procédés améliorés de production d'une solution contenant des polysaccharides capsulaires de poids moléculaire élevé isolés de Streptococcus pneumoniae ayant des liaisons phosphodiester entre les unités répétées de saccharides. Dans certains procédés, le CO2 est alimenté dans une culture en fermenteur des cellules bactériennes de Streptococcus pneumoniae qui produisent des sérotypes de polysaccharides capsulaires contenant des liaisons phosphodiester entre les unités répétées de saccharides. Des sérotypes exemplaires de Streptococcus pneumoniae contenant une liaison phosphodiester entre les unités répétées de saccharides comprennent les sérotypes 6A, 6B, 19A, et 19F. L'alimentation de la culture en fermenteur en CO2 comprend l'ajout d'ions bicarbonate à la culture en fermenteur, l'ajout d’ions carbonate à la culture en fermenteur, l'ajout de mélanges d'ions bicarbonate et carbonate à la culture en fermenteur, et le recouvrement de la culture en fermenteur avec du CO2.
Latest bibliographic data on file with the International Bureau