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1. WO2010077634 - ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION

Publication Number WO/2010/077634
Publication Date 08.07.2010
International Application No. PCT/US2009/067104
International Filing Date 08.12.2009
Chapter 2 Demand Filed 04.10.2010
IPC
C07K 16/28 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61K 39/395 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
507Comprising a combination of two or more separate antibodies
A61K 31/7068
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7068having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61K 39/39558
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
39558against tumor tissues, cells, antigens
Applicants
  • GENENTECH, INC. [US]/[US] (AE, AG, AL, AM, AO, AU, AZ, BA, BB, BF, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PE, PG, PH, RS, RU, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TJ, TM, TN, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • F. HOFFMANN-LA ROCHE AG [CH]/[CH] (AT, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, SE, SI, SK, SM, TR)
  • IRVING, Bryan [US]/[US] (UsOnly)
  • CHEUNG, Jeanne [US]/[US] (UsOnly)
  • CHIU, Henry [US]/[US] (UsOnly)
  • LEHAR, Sophie, M. [US]/[US] (UsOnly)
  • MAECKER, Heather [US]/[US] (UsOnly)
  • MARIATHASAN, Sanjeev [CA]/[US] (UsOnly)
  • WU, Yan [US]/[US] (UsOnly)
Inventors
  • IRVING, Bryan
  • CHEUNG, Jeanne
  • CHIU, Henry
  • LEHAR, Sophie, M.
  • MAECKER, Heather
  • MARIATHASAN, Sanjeev
  • WU, Yan
Agents
  • SVOBODA, Craig, G.
Priority Data
61/121,09209.12.2008US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-PD-L1 ANTIBODIES AND THEIR USE TO ENHANCE T-CELL FUNCTION
(FR) ANTICORPS ANTI-PD-L1 ET LEUR UTILISATION POUR AMÉLIORER LA FONCTION DES LYMPHOCYTES T
Abstract
(EN) The present application relates to anti-PD-L1 antibodies, nucleic acid encoding the same, therapeutic compositions thereof, and their use enhance T-cell function to upregulate cell-mediated immune responses and for the treatment of T cell dysfunctional disorders, including infection (e.g., acute and chronic) and tumor immunity.
(FR) La présente invention concerne des anticorps anti-PD-L1, un acide nucléique les codant, leurs compositions thérapeutiques et leur utilisation pour améliorer la fonction des lymphocytes T en vue de réguler positivement les réponses immunitaires à médiation cellulaire et pour le traitement de troubles dysfonctionnels des lymphocytes T, y compris une infection (par ex. aiguë et chronique) et l'immunité tumorale.
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