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1. WO2008067115 - SELECTIVE IMMUNODEPLETION OF ENDOGENOUS STEM CELL NICHE FOR ENGRAFTMENT

Publication Number WO/2008/067115
Publication Date 05.06.2008
International Application No. PCT/US2007/083529
International Filing Date 02.11.2007
IPC
A01N 63/00 2006.1
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
A61K 2039/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
54characterised by the route of administration
A61K 35/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
A61K 39/3955
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
39533against materials from animals
3955against proteinaceous materials, e.g. enzymes, hormones, lymphokines
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
Applicants
  • THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY [US]/[US] (AllExceptUS)
  • WEISSMAN, Irving L. [US]/[US] (UsOnly)
  • CZECHOWICZ, Agnieszka [US]/[US] (UsOnly)
  • BHATTACHARYA, Deepta [US]/[US] (UsOnly)
  • KRAFT, Daniel [US]/[US] (UsOnly)
Inventors
  • WEISSMAN, Irving L.
  • CZECHOWICZ, Agnieszka
  • BHATTACHARYA, Deepta
  • KRAFT, Daniel
Agents
  • SHERWOOD, Pamela J.
Priority Data
60/856,43503.11.2006US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) SELECTIVE IMMUNODEPLETION OF ENDOGENOUS STEM CELL NICHE FOR ENGRAFTMENT
(FR) IMMUNODÉPLÉTION SÉLECTIVE DE NICHE DE CELLULES SOUCHES ENDOGÈNES POUR GREFFE
Abstract
(EN) The present invention provides a clinically applicable method of stem cell transplantation that facilitates engraftment and reconstitutes immunocompetence of the recipient without requiring radiotherapy or chemotherapy, and without development of GVHD or graft rejection. Aspects of the present invention are based on the discovery that the depletion of the endogenous stem cell niche facilitates efficient engraftment of stem cells into that niche. In particular, the present invention combines the use of selective ablation of endogenous stem cells, in combination with the administration to the recipient of exogenous stem cells, resulting in efficient, long-term engraftment and tolerance.
(FR) La présente invention concerne un procédé cliniquement applicable de transplantation de cellules souches qui facilite la greffe et qui reconstitue l'immunocompétence du récipiendaire sans nécessité de radiothérapie ni de chimiothérapie et, sans développement de GVHD ni de rejet de greffe. Des aspects de la présente invention se fondent sur la découverte que la déplétion de niche de cellules souches endogènes facilite une greffe efficace de cellules souches dans cette niche. En particulier, la présente invention combine l'utilisation de l'ablation sélective de cellules souches endogènes avec l'administration au récipiendaire de cellules souches exogènes, permettant d'obtenir une greffe et une tolérance efficace dans le long terme.
Latest bibliographic data on file with the International Bureau