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1. WO2007130626 - BIVALENT SMAC MIMETICS AND THE USES THEREOF

Publication Number WO/2007/130626
Publication Date 15.11.2007
International Application No. PCT/US2007/010924
International Filing Date 04.05.2007
IPC
A61K 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
CPC
A61K 31/407
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
407condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
A61K 38/191
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
191Tumor necrosis factors [TNF], e.g. lymphotoxin [LT], i.e. TNF-beta
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 519/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
519Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Applicants
  • THE REGENTS OF THE UNIVERSITY OF MICHIGAN [US]/[US] (AllExceptUS)
  • WANG, Shaomeng [US]/[US] (UsOnly)
  • SUN, Haiying [CN]/[US] (UsOnly)
  • QIN, Dongguang [CN]/[US] (UsOnly)
  • NIKOLOVSKA-COLESKA, Zaneta [MK]/[US] (UsOnly)
  • LU, Jianfeng [CN]/[US] (UsOnly)
  • QIU, Su [CN]/[US] (UsOnly)
  • PENG, Yuefeng [CN]/[US] (UsOnly)
  • CAI, Qian [CN]/[US] (UsOnly)
Inventors
  • WANG, Shaomeng
  • SUN, Haiying
  • QIN, Dongguang
  • NIKOLOVSKA-COLESKA, Zaneta
  • LU, Jianfeng
  • QIU, Su
  • PENG, Yuefeng
  • CAI, Qian
Agents
  • GOETZ, Robert, A.
Priority Data
60/798,01805.05.2006US
60/923,41513.04.2007US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIVALENT SMAC MIMETICS AND THE USES THEREOF
(FR) AGENTS MIMÉTIQUES BIVALENTS DE LA SMAC ET LEURS UTILISATIONS
Abstract
(EN)
The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.
(FR)
L'invention concerne des agents mimétiques bivalents de la protéine Smac qui agissent en tant qu'inhibiteurs de l'inhibiteur des protéines de l'apoptose. L'invention concerne également l'utilisation de ces agents mimétiques pour induire une mort cellulaire programmée et pour sensibiliser les cellules à des inducteurs de l'apoptose.
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