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1. WO2014097116 - STABILIZED INSULIN-LIKE GROWTH FACTOR POLYPEPTIDES

Publication Number WO/2014/097116
Publication Date 26.06.2014
International Application No. PCT/IB2013/060985
International Filing Date 16.12.2013
IPC
C07K 14/65 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
65Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 17/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
02for treating wounds, ulcers, burns, scars, keloids, or the like
A61P 19/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
A61P 21/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
21Drugs for disorders of the muscular or neuromuscular system
C07K 14/65
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
575Hormones
65Insulin-like growth factors (Somatomedins), e.g. IGF-1, IGF-2
Applicants
  • NOVARTIS AG [CH]/[CH] (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
  • FORNARO, Mara [IT]/[CH] (US)
  • HUBER, Thomas [CH]/[CH] (US)
  • ZURINI, Mauro [CH]/[CH] (US)
Inventors
  • FORNARO, Mara
  • HUBER, Thomas
  • ZURINI, Mauro
Common Representative
  • NOVARTIS AG
Priority Data
61/738,47518.12.2012US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) STABILIZED INSULIN-LIKE GROWTH FACTOR POLYPEPTIDES
(FR) POLYPEPTIDES STABILISÉS DE FACTEUR DE CROISSANCE DE TYPE INSULINE
Abstract
(EN) This invention is in the field of IGF-1 modifications. In particular, it relates to modified IGF- polypeptides and modified IGF-1 precursor polypeptides wherein the cleavage of E-peptide is prevented. The invention also relates to the use of such polypeptides for treating muscle diseases and disorders.
(FR) Cette invention concerne le domaine des modifications d'IGF-1. En particulier, l'invention concerne des polypeptides IGF modifiés et des polypeptides précurseurs d'IGF-1 modifiés où le clivage du peptide E est empêché. L'invention concerne également l'utilisation de tels polypeptides pour le traitement de maladies et de troubles musculaires.
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