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1. WO2019121762 - METHOD OF ASSESSING GROWTH HORMONE DEFICIENCY IN HUMANS BY A MACIMORELIN CONTAINING COMPOSITION

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Publication Number WO/2019/121762
Publication Date 27.06.2019
International Application No. PCT/EP2018/085622
International Filing Date 18.12.2018
IPC
G01N 33/74 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74involving hormones
G01N 33/50 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
CPC
G01N 2333/61
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2333Assays involving biological materials from specific organisms or of a specific nature
435from animals; from humans
575Hormones
61Growth hormones [GH] (Somatotropin)
G01N 2800/048
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2800Detection or diagnosis of diseases
04Endocrine or metabolic disorders
048Pituitary or hypothalamic - pituitary relationships, e.g. vasopressin or ADH related
G01N 33/49
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
483Physical analysis of biological material
487of liquid biological material
49Blood
G01N 33/5091
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5091for testing the pathological state of an organism
G01N 33/74
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
74involving hormones ; or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
Applicants
  • AETERNA ZENTARIS GMBH [DE]/[DE]
Inventors
  • AMMER, Nicola
  • MUELLER, Gilbert
  • SACHSE, Richard
  • SINDERMANN, Herbert
Priority Data
62/607,86619.12.2017US
62/609,05921.12.2017US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF ASSESSING GROWTH HORMONE DEFICIENCY IN HUMANS BY A MACIMORELIN CONTAINING COMPOSITION
(FR) MÉTHODE D'ÉVALUATION D'UNE DÉFICIENCE EN HORMONE DE CROISSANCE CHEZ DES ÊTRES HUMAINS PAR UNE COMPOSITION CONTENANT DE LA MACIMORÉLINE
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Abstract
(EN) The present invention relates to a method for measuring growth hormone level in a human or animal subject, including a method of assessing pituitary-related growth hormone deficiency in a human or animal subject. The method comprises oral administration of a macimorelin containing composition to said subject, collecting one, two or three post- administration samples within a range of 25 to 95 minutes after administration from said subject, and comparing the level of growth hormone in the single sample, the two or three samples to a single threshold value. The method can be used for diagnosing pituitary- related growth hormone deficiency when the all levels of determined growth hormone are below the single threshold value.
(FR) La présente invention concerne une méthode de mesure du taux d'hormone de croissance chez un sujet humain ou animal, comprenant une méthode d'évaluation d'une déficience en hormone de croissance liée à l'hypophyse chez un sujet humain ou animal. La méthode comprend l'administration orale d'une composition contenant de la macimoréline audit sujet, la collecte d'un, de deux ou de trois échantillons après l'administration dans une plage de 25 à 95 minutes après l'administration à partir dudit sujet, et la comparaison du taux d'hormone de croissance dans l'échantillon unique, les deux ou trois échantillons à une valeur de seuil unique. La méthode peut être utilisée pour diagnostiquer une déficience en hormone de croissance liée à l'hypophyse lorsque tous les taux d'hormone de croissance déterminée sont au-dessous de la valeur de seuil unique.
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