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1. WO2019115547 - PSMA LIGANDS FOR IMAGING AND ENDORADIOTHERAPY

Publication Number WO/2019/115547
Publication Date 20.06.2019
International Application No. PCT/EP2018/084399
International Filing Date 11.12.2018
IPC
A61K 51/04 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
CPC
A61K 2121/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2121Preparations for use in therapy
A61K 2123/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2123Preparations for testing in vivo
A61K 51/0482
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
0474complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
0482chelates from cyclic ligands, e.g. DOTA
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 257/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
257Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
Applicants
  • TECHNISCHE UNIVERSITÄT MÜNCHEN [DE]/[DE]
Inventors
  • WESTER, Hans-Jürgen
  • SCHMIDT, Alexander
  • PARZINGER, Mara
Agents
  • VOSSIUS & PARTNER (NO 31)
Priority Data
17206510.411.12.2017EP
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PSMA LIGANDS FOR IMAGING AND ENDORADIOTHERAPY
(FR) LIGANDS DE PSMA POUR L'IMAGERIE ET L'ENDORADIOTHÉRAPIE
Abstract
(EN) The present disclosure relates to imaging and endoradiotherapy of diseases involving prostate-specific membrane antigen (PSMA). Provided are compounds which bind or inhibit PSMA and furthermore carry at least one moiety which is amenable to radiolabeling. Provided are also medical uses of such compounds.
(FR) La présente invention concerne l'imagerie et l'endoradiothérapie de maladies impliquant un antigène membranaire spécifique de la prostate (PSMA). L'invention concerne des composés qui se lient ou inhibent le PSMA et portent en outre au moins une fraction qui peut être radiomarquée. L'invention concerne également des utilisations médicales de tels composés.
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