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1. WO2015004240 - NALMEFENE SALTS AS MEDICAMENTS FOR REDUCING ALCOHOL CONSUMPTION OR FOR PREVENTING EXCESSIVE ALCOHOL CONSUMPTION

Publication Number WO/2015/004240
Publication Date 15.01.2015
International Application No. PCT/EP2014/064819
International Filing Date 10.07.2014
IPC
C07D 489/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
489Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro furan ring systems, e.g. derivatives of -morphinan of the formula:
06with a hetero atom directly attached in position 14
08Oxygen atom
A61K 31/485 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
485Morphinan derivatives, e.g. morphine, codeine
A61P 25/30 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
CPC
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/30
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
A61P 25/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
30for treating abuse or dependence
32Alcohol-abuse
C07D 489/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
489Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
06with a hetero atom directly attached in position 14
08Oxygen atom
Applicants
  • H. LUNDBECK A/S [DK]/[DK]
Inventors
  • DE DIEGO, Heidi Lopez
Priority Data
PA 2013 0042111.07.2013DK
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NALMEFENE SALTS AS MEDICAMENTS FOR REDUCING ALCOHOL CONSUMPTION OR FOR PREVENTING EXCESSIVE ALCOHOL CONSUMPTION
(FR) SELS DE NALMÉFÈNE EN TANT QUE MÉDICAMENTS POUR RÉDUIRE LA CONSOMMATION D'ALCOOL OU EMPÊCHER LA CONSOMMATION EXCESSIVE D'ALCOOL
Abstract
(EN)
The present invention relates to new nalmefene salts which salts fall within at least one of the two following categories: non-hydrate forming salts and non-solvate forming salts. In particular, the invention relates to the hydrogen adipate salt, the hydrogen malonate salt, the lactate salt, the hydrogen fumarate salt, the hydrogen succinate salt, the benzene sulfonate salt, the hydrogen maleate salt and the salicylate salt of nalmefene. The present invention also relates to such salts for use in therapy.
(FR)
La présente invention concerne de nouveaux sels de nalméfène, lesdits sels appartenant à l'une au moins des deux catégories suivantes : sels ne formant pas d'hydrates et sels ne formant pas de solvates. L'invention porte en particulier sur le sel hydrogénoadipate, le sel hydrogénomalonate, le sel lactate, le sel hydrogénofumarate, le sel hydrogénosuccinate, le sel benzène-sulfonate, le sel hydrogénomaléate et le sel salicylate de nalméfène. La présente invention concerne également l'emploi thérapeutique de tels sels.
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