WO2013097911 COMPOSITION FOR NASAL APPLICATION WITH IMPROVED STABILITY

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Publication Number WO/2013/097911

Publication Date 04.07.2013

International Application No. PCT/EP2012/003995

International Filing Date 25.09.2012

Chapter 2 Demand Filed 26.10.2012

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Applicants

MARIA CLEMENTINE MARTIN KLOSTERFRAU VERTRIEBSGESELLSCHAFT MBH [DE]/[DE] (AllExceptUS)
GREVE, Harald [DE]/[DE] (US)

Inventors

GREVE, Harald

Agents

VON ROHR

Priority Data

10 2011 122 588.2		30.12.2011		DE
10 2012 005 452.1		20.03.2012		DE

Publication Language German (de)

Filing Language German (DE)

Designated States

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Title

(DE) ZUSAMMENSETZUNG FÜR DIE NASALE APPLIKATION MIT VERBESSERTER STABILITÄT

(EN) COMPOSITION FOR NASAL APPLICATION WITH IMPROVED STABILITY

(FR) COMPOSITION À STABILITÉ AMÉLIORÉE POUR ADMINISTRATION NASALE

Abstract

(DE) Die Erfindung betrifft eine für die topische, insbesondere nasale, vorzugsweise intranasale Applikation bestimmte pharmazeutische Zusammensetzung mit verbesserter Stabilität sowie deren Verwendung und eine diese pharmazeutische Zusammensetzung enthaltende Applikationsvorrichtung.

(EN) The invention relates to a pharmaceutical composition with improved stability for topical, particularly nasal, preferably intranasal application, to the use thereof, and to an application device containing said pharmaceutical composition.

(FR) L'invention concerne une composition pharmaceutique destinée à une administration topique, en particulier nasale, de préférence intranasale, et présentant une stabilité améliorée, ainsi que son utilisation, et un dispositif d'administration contenant ladite composition pharmaceutique.

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
164	of a carboxylic acid with an aminoalcohol, e.g. ceramides

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
415	1,2-Diazoles

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41	having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164	1,3-Diazoles
4174	Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
33	Heterocyclic compounds
395	having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495	having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505	Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519	ortho- or peri-condensed with heterocyclic rings
525	Isoalloxazines, e.g. riboflavins, vitamin B₂

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11	Drugs for disorders of the respiratory system
02	Nasal agents, e.g. decongestants

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1. WO2013097911 - COMPOSITION FOR NASAL APPLICATION WITH IMPROVED STABILITY

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
16	containing nitrogen, ; e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
18	Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
186	Quaternary ammonium compounds, e.g. benzalkonium chloride or cetrimide

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06	Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
22	Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47	Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30	Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36	Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin