(EN) Compositions comprising a nutritionally or pharmaceutically effective dosage of an extract of Salvia officinalisand an acceptable carrier are provided. The compositions show particular potential in the treatment of age-related pathologies in humans or animals. The extracts are obtained from varieties and cultivars of Salvia officinalisthat possess a unique chemical fingerprint that includes unusually low thujone content in the leaf. When tested in C. elegansscreening assays compositions that comprise the extract elicit an increase in mean chronological lifespan (CLS)in theC. eleganspopulation of at least 10%.