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1. NZ740946 - 3' UTR SEQUENCES FOR STABILIZATION OF RNA

Office
New Zealand
Application Number 740946
Application Date 22.03.2018
Publication Number 740946
Publication Date 23.03.2018
Publication Kind A1
IPC
C12N 15/67
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
67General methods for enhancing the expression
Applicants BioNTech RNA Pharmaceuticals GmbH
TRON - Translationale Onkologie an der Universitätsmedizin der Johannes Gutenberg-Universität Mainz gGmbH
Inventors SAHIN, Ugur
BEISSERT, Tim
ORLANDINI VON NIESSEN, Alexandra
FESSER, Stephanie
VALLAZZA, Britta
KUHN, Andreas
POLEGANOV, Marco Alexander
Agents FB Rice Pty Ltd
Priority Data PCT/EP2015/073180 07.10.2015 EP
Title
(EN) 3' UTR SEQUENCES FOR STABILIZATION OF RNA
Abstract
(EN)
The present invention relates to stabilization of RNA, in particular mRNA, and an increase in mRNA translation. The present invention particularly relates to a modification of RNA, in particular in vitro-transcribed RNA, resulting in increased transcript stability and/or translation efficiency. According to the invention, it was demonstrated that certain sequences in the 3'- untranslated region (UTR) of an RNA molecule improve stability and translation efficiency.