NZ586109 NEW POLYMORPHIC FORMS OF N-[4-(TRIFLUOROMETHYL)BENZYL]-4-METHOXYBUTYRAMIDE

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Application Number 586109

Application Date 14.06.2010

Publication Number 586109

Publication Date 25.05.2012

Publication Kind A

IPC

CPC

Applicants Laboratorio Farmaceutico C.T. S.R.L

Inventors CACCIAGLIA, Roberto
FERRARI, Massimo

Agents Spruson & Ferguson Pty Ltd

Priority Data 07120551 13.11.2007 EP

Title

(EN) NEW POLYMORPHIC FORMS OF N-[4-(TRIFLUOROMETHYL)BENZYL]-4-METHOXYBUTYRAMIDE

Abstract

(EN) Patent 586109 Disclosed are polymeric forms of N-[4-(trifluoromethyl)benzyl]-4-methoxybutyramide of Formula (I) having the following peaks at the diffraction degrees (2-theta) in the X-ray powder diffraction pattern plus or minus 0.2: 9.7; 12.0; 18.0; 24.1; 25.9. Also disclosed is polymeric form B having the following peaks at the diffraction degrees (2-theta) in the X-ray powder diffraction pattern plus or minus 0.2: 11.7; 19.8; 22.3; 23.6. Further disclosed is the process for making polymorphic forms A and B, a pharmaceutical composition comprising polymorphs A or B and the use of the Forms A and B in the manufacture of a medicament for treating drug addiction and alcoholism and reducing the voluntary consumption of ethyl alcohol in the treatment of abstinences syndrome.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
235	Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02	having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04	the carbon skeleton being acyclic and saturated
06	having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
165	having aromatic rings, e.g. colchicine, atenolol, progabide

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
P	SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25	Drugs for disorders of the nervous system
30	for treating abuse or dependence

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
C	ACYCLIC OR CARBOCYCLIC COMPOUNDS
235	Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
02	having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
04	the carbon skeleton being acyclic and saturated
06	having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms

A	HUMAN NECESSITIES
61	MEDICAL OR VETERINARY SCIENCE; HYGIENE
K	PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31	Medicinal preparations containing organic active ingredients
16	Amides, e.g. hydroxamic acids
165	having aromatic rings, e.g. colchicine, atenolol, progabide

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1. NZ586109 - NEW POLYMORPHIC FORMS OF N-[4-(TRIFLUOROMETHYL)BENZYL]-4-METHOXYBUTYRAMIDE

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
B	GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200	Indexing scheme relating to specific properties of organic compounds
13	Crystalline forms, e.g. polymorphs