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1. (NZ544988) Nucleobase phosphonate analogs for antiviral treatment

Office : New Zealand
Application Number: 544988 Application Date: 30.07.2004
Publication Number: 544988 Publication Date: 27.11.2009
Grant Number: Grant Date: 11.03.2010
Publication Kind : B
Prior PCT appl.: Application Number:PCTUS2004024922 ; Publication Number: Click to see the data
IPC:
C07F 9/6512
C07F 9/653
A61K 31/675
A61P 31/12
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
645
having two nitrogen atoms as the only ring hetero atoms
6509
Six-membered rings
6512
having the nitrogen atoms in positions 1 and 3
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6527
having nitrogen and oxygen atoms as the only ring hetero atoms
653
Five-membered rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants: Gilead Sciences, Inc.
Inventors: Krawczyk, Steven H
Agents: AJ PARK
Priority Data: 03 491123 30.07.2003 US
Title: (EN) Nucleobase phosphonate analogs for antiviral treatment
Abstract:
(EN) Patent 544988 Disclosed is a compound of the formula (I) wherein X2 is selected from O, NR and S; Y1 is independently O, S, NR, or N-R2; Y2 is independently O, NR, N-NR2-S(O)M2-, or ���S(O)M2-S(O)M2-; NUCLEOBASE is selected from adenine, guanine, aminopurine, 2-amino-6-chloropurine, 2,6-diaminopurine, hypoxanthine, isoguanine, 6-thioguanine, O6-methylguanine and N6-methyladenine, and wherein the rest of the substituents are disclosed within the specification or a pharmaceutically acceptable salt thereof. Also disclosed is the use of the above compound in the manufacture of a medicament for the treatment or prevention of the symptoms or effects of HIV infection in an infected animal.
Also published as:
EP1656387JP2007500727US20060252729CA2533966AU2004260789WO/2005/012324