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1. NZ541139 - Contrast media formulations having improved biological tolerance

Office
New Zealand
Application Number 541139
Application Date 07.07.2005
Publication Number 541139
Publication Date 31.07.2008
Grant Number 541139
Grant Date 13.11.2008
Publication Kind B
IPC
A61K 49/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
04X-ray contrast preparations
A61K 49/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08characterised by the carrier
10Organic compounds
CPC
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
A61K 49/0433
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
04X-ray contrast preparations
0433containing an organic halogenated X-ray contrast-enhancing agent
A61K 49/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
A61K 49/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
04X-ray contrast preparations
Applicants Biophysica, Inc.
Inventors Terry, Ronald C
Sovak, Milos
Seligson, Allen L
Agents PHILLIPS ORMONDE FITZPATRICK
Title
(EN) Contrast media formulations having improved biological tolerance
Abstract
(EN) Patent 541139 Disclosed is a contrast formulation having improved biological tolerance and a physiologically acceptable pH and osmololity comprising a sterile aqueous solution of iosimenol; and a buffer comprising TRIS or N-methyl glucamine and citrate, wherein the molar ration of TRIS of N-methyl glucamine to citrate is in the range of greater than 3:1 to about 10:1 and said TRIS or N-methyl glucamine is at a concentration in the range of about 5mM to 40mM.