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1. (NZ539264) Pre-organized tricyclic integrase inhibitor compounds

Office : New Zealand
Application Number: 539264 Application Date: 16.10.2003
Publication Number: 539264 Publication Date: 31.08.2007
Grant Number: Grant Date: 13.12.2007
Publication Kind : B
Prior PCT appl.: Application Number:PCTUS2003032666 ; Publication Number: Click to see the data
IPC:
C07D 471/04
C07D 498/20
C07D 487/04
C07D 207/404
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
498
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
12
in which the condensed system contains three hetero rings
20
Spiro-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
207
Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30
having two double bonds between ring members or between ring members and non-ring members
34
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36
Oxygen or sulfur atoms
40
2,5-Pyrrolidine-diones
404
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
Applicants: Gilead Sciences, Inc.
Inventors: Chen, James M
Chen, Xiaowu
Fardis, Maria
Jin, Haolun
Kim, Choung U
Schacherer, Laura N
Agents: AJ PARK
Priority Data: 02 418963 16.10.2002 US
03 478783 16.06.2003 US
Title: (EN) Pre-organized tricyclic integrase inhibitor compounds
Abstract:
(EN) Patent 539264 Tricyclic compounds according to the structure shown below in formula (I), protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed. A1 and A2 are moieties forming a five, six, or seven membered ring. L is a bond or a linker connecting a ring atom of Ar to N. X is O, S, or substituted nitrogen. Ar is aryl or heteroaryl. Q is N, +NR, or CR4. The aryl carbons may be independently substituted with substituents other than hydrogen. The compounds may include prodrug moieties covalently attached at any site. The variables shown in formula (I) are further defined in the specification.
Also published as:
HRP20050431AIS7845NO20052378PL377966MXPA/a/2005/003950APAP 1858
KR1020050087787VN11924ZA2005/03734IL167843EP1558613JP2006514099
US20060217410CN1726212CA2501881EA200500660AU2003301306ID046.4164
IN1969/DELNP/2005WO/2004/035576