Processing

Please wait...

Settings

Settings

Goto Application

1. MYPI 2016000416 - 1, 2, 4-OXADIAZOLE DERIVATIVES AS IMMUNOMODULATORS

Office
Malaysia
Application Number PI 2016000416
Application Date 05.09.2014
Publication Number PI 2016000416
Publication Date 06.03.2015
Publication Kind A
IPC
C07D 271/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
271Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
02not condensed with other rings
061,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
Applicants AURIGENE DISCOVERY TECHNOLOGIES LIMITED
Inventors NAREMADDEPALLI, SEETHARAMAIAH SETTY SUDARSHAN
RAMACHANDRA, MURALIDHARA
SASIKUMAR, POTTAYIL GOVINDAN NAIR
Agents CHRISTOPHER PAUL HEMINGWAY
Priority Data 4011/CHE/2013 06.09.2013 IN
Title
(EN) 1, 2, 4-OXADIAZOLE DERIVATIVES AS IMMUNOMODULATORS
Abstract
(EN) The present invention relates to 1,2,4-oxadiazole and 1,2,4-thiadiazole compounds as therapeutic agents capable of inhibiting the programmed cell death 1 (PD1) signaling pathway. The invention also refers to derivatives of the therapeutic agents. The invention also encompasses the use of the said therapeutic agents and derivatives for treatment of disorders via immunopotentiation comprising inhibition of immunosuppressive signal induced due to PD-1, PD-L1, or PD-L2 and therapies using them.